@article{fdi:010080000,
  title = {{E}arly {ART} initiation improves {HIV} status disclosure and social support in people living with {HIV}, linked to care within a universal test and treat program in rural {S}outh {A}frica ({ANRS} 12249 {T}as{P} {T}rial)},
  author = {{F}iorentino, {M}. and {N}ishimwe, {M}. and {P}rotopopescu, {C}. and {I}wuji, {C}. and {O}kesola, {N}. and {S}pire, {B}. and {O}rne-{G}liemann, {J}. and {M}c{G}rath, {N}. and {P}illay, {D}. and {D}abis, {F}. and {L}armarange, {J}oseph and {B}oyer, {S}. and {ANRS} 12249 {T}a{SP} {S}tudy {G}roup},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e investigated the effect of early antiretroviral treatment ({ART}) initiation on {HIV} status disclosure and social support in a cluster-randomized, treatment-as-prevention ({T}as{P}) trial in rural {S}outh {A}frica. {I}ndividuals identified {HIV}-positive after home-based testing were referred to trial clinics where they were invited to initiate {ART} immediately irrespective of {CD}4 count (intervention arm) or following national guidelines (control arm). {W}e used {P}oisson mixed effects models to assess the independent effects of (a) time since baseline clinical visit, (b) trial arm, and (c) {ART} initiation on {HIV} disclosure (n = 182) and social support (n = 152) among participants with a {CD}4 count > 500 cells/mm(3) at baseline. {D}isclosure and social support significantly improved over follow-up in both arms. {D}isclosure was higher (incidence rate ratio [95% confidence interval]: 1.24 [1.04; 1.48]), and social support increased faster (1.22 [1.02; 1.46]) in the intervention arm than in the control arm. {ART} initiation improved both disclosure and social support (1.50 [1.28; 1.75] and 1.34 [1.12; 1.61], respectively), a stronger effect being seen in the intervention arm for social support (1.50 [1.12; 2.01]). {B}esides clinical benefits, early {ART} initiation may also improve psychosocial outcomes. {T}his should further encourage countries to implement universal test-and-treat strategies.},
  keywords = {{HIV} ; {E}arly antiretroviral treatment ; {T}est and treat ; {HIV} status disclosure ; {S}ocial support ; {S}outh africa ; {AFRIQUE} {DU} {SUD}},
  booktitle = {},
  journal = {{AIDS} and {B}ehavior},
  volume = {25},
  numero = {4},
  pages = {1306--1322},
  ISSN = {1090-7165},
  year = {2021},
  DOI = {10.1007/s10461-020-03101-y},
  URL = {https://www.documentation.ird.fr/hor/fdi:010080000},
}