Messi L. M. auteur aut IRD Note O. P. auteur aut IRD Mbing J. N. auteur aut IRD Lavedan P. auteur aut IRD Vedrenne M. auteur aut IRD Ouedraogo N. auteur aut IRD Carraz Maëlle auteur aut IRD Bourgeade-Delmas Sandra auteur aut IRD Pegnyemb D. E. auteur aut IRD Haddad Mohamed auteur aut IRD text journalArticle eng text/pdf born digital access The chemical investigation of the flowers and twigs of Calliandra calothyrsus (Fabaceae) led to the isolation of three new oleanane-type triterpenoid saponins, named calothyrsusosides A-C (1-3). Their structures were established by direct interpretation of their spectral data, mainly HRESIMS, 1D NMR and 2D NMR (H-1, H-1 NMR DOSY, C-13 NMR, COSY, HSQC, HMBC, HSQC-TOCSY and NOESY) and by comparison with literature data. Compounds 1 and 2 were tested for their antiproliferative activity against two digestive carcinoma human cell lines: Hep3B (hepatocellular carcinoma) and Caco-2 (epithelial colorectal adenocarcinoma). Both compounds exhibited an antiproliferative activity against the Hep3B cell line, with IC50 values of 6.0 and 6.5 mu M, respectively, while no effect was detected against the epithelial colorectal adenocarcinoma Caco-2 (CC50 > 25 mu M). specialized Calliandra calothyrsus Fabaceae Triterpenoid saponins Calothyrsusoside Cytotoxicity 076 050 020 146 104669 [9 ] + [Corrigendum, 1 p.] 2020 0367-326X https://www.documentation.ird.fr/hor/fdi:010079929 10.1016/j.fitote.2020.104669 0367-326X [F B010079929] https://www.documentation.ird.fr/hor/fdi:010079929 https://www.documentation.ird.fr/intranet/publi/2020/11/010079929.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2020-12-08 2025-02-24 fdi:010079929 fre