@article{fdi:010079929,
  title = {{T}riterpenoid saponins from {C}alliandra calothyrsus {M}eisn. and their antiproliferative activity against two digestive carcinoma human cell lines  [+ {C}orrigendum, vol. 175, 2024, 105934]},
  author = {{M}essi, {L}. {M}. and {N}ote, {O}. {P}. and {M}bing, {J}. {N}. and {L}avedan, {P}. and {V}edrenne, {M}. and {O}uedraogo, {N}. and {C}arraz, {M}a{\¨e}lle and {B}ourgeade-{D}elmas, {S}andra and {P}egnyemb, {D}. {E}. and {H}addad, {M}ohamed},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he chemical investigation of the flowers and twigs of {C}alliandra calothyrsus ({F}abaceae) led to the isolation of three new oleanane-type triterpenoid saponins, named calothyrsusosides {A}-{C} (1-3). {T}heir structures were established by direct interpretation of their spectral data, mainly {HRESIMS}, 1{D} {NMR} and 2{D} {NMR} ({H}-1, {H}-1 {NMR} {DOSY}, {C}-13 {NMR}, {COSY}, {HSQC}, {HMBC}, {HSQC}-{TOCSY} and {NOESY}) and by comparison with literature data. {C}ompounds 1 and 2 were tested for their antiproliferative activity against two digestive carcinoma human cell lines: {H}ep3{B} (hepatocellular carcinoma) and {C}aco-2 (epithelial colorectal adenocarcinoma). {B}oth compounds exhibited an antiproliferative activity against the {H}ep3{B} cell line, with {IC}50 values of 6.0 and 6.5 mu {M}, respectively, while no effect was detected against the epithelial colorectal adenocarcinoma {C}aco-2 ({CC}50 > 25 mu {M}).},
  keywords = {{C}alliandra calothyrsus ; {F}abaceae ; {T}riterpenoid saponins ; {C}alothyrsusoside ; {C}ytotoxicity},
  booktitle = {},
  journal = {{F}itoterapia},
  volume = {146},
  numero = {},
  pages = {104669 [9 ] + [{C}orrigendum, 1 p.]},
  ISSN = {0367-326{X}},
  year = {2020},
  DOI = {10.1016/j.fitote.2020.104669},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079929},
}