Trinel M. auteur aut IRD Le Lamer A. C. auteur aut IRD Jullian Valérie auteur aut IRD Jacquemin D. auteur aut IRD Graton J. auteur aut IRD Cristofoli V. auteur aut IRD Crossay E. auteur aut IRD Yassine M. auteur aut IRD Rolland C. auteur aut IRD Vergnolle N. auteur aut IRD Mejia K. auteur aut IRD Cabanillas B. J. auteur aut IRD Racaud-Sultan C. auteur aut IRD Fabre N. auteur aut IRD text journalArticle eng text/pdf born digital access Hura crepitans (Euphorbiaceae) is a tree from South America that produces an irritant latex used as a fish poison. A bio-guided fractionation of an ethanolic extract of the latex led to the isolation and structural identification of three known daphnane-type diterpenes (1-3) including huratoxin (1), together with two new analogs (4, 5). Compound 1 was found to exhibit significant and selective cell growth inhibition against the colorectal cancer cell line Caco-2, with morphological modifications suggesting formations mimicking the intestinal crypt architecture. The underlying mechanism of 1 was further investigated, in comparison with 12-O-tetradecanoylphorbol-13-acetate (TPA), revealing two different mechanisms. specialized Hura crepitans Daphnane diterpenes Colorectal cancer Cytotoxicity Epithelial morphogenesis 050 076 020 103 104132 [13 ] 2020 0045-2068 https://www.documentation.ird.fr/hor/fdi:010079802 10.1016/j.bioorg.2020.104132 0045-2068 [F B010079802] https://www.documentation.ird.fr/hor/fdi:010079802 https://www.documentation.ird.fr/intranet/publi/2020/10/010079802.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2020-11-12 2025-02-24 fdi:010079802 fre