Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Bioorganic Chemistry 104132 [13 ] Hura crepitans Daphnane diterpenes Colorectal cancer Cytotoxicity Epithelial morphogenesis 2020 fdi:010079802 ENG Bioorganic Chemistry 0045-2068 ISI:000575793100009 10.1016/j.bioorg.2020.104132 https://www.documentation.ird.fr/hor/fdi:010079802 https://www.documentation.ird.fr/intranet/publi/2020/10/010079802.pdf 103 Horizon (IRD) Hura crepitans (Euphorbiaceae) is a tree from South America that produces an irritant latex used as a fish poison. A bio-guided fractionation of an ethanolic extract of the latex led to the isolation and structural identification of three known daphnane-type diterpenes (1-3) including huratoxin (1), together with two new analogs (4, 5). Compound 1 was found to exhibit significant and selective cell growth inhibition against the colorectal cancer cell line Caco-2, with morphological modifications suggesting formations mimicking the intestinal crypt architecture. The underlying mechanism of 1 was further investigated, in comparison with 12-O-tetradecanoylphorbol-13-acetate (TPA), revealing two different mechanisms. 050 ; 076 ; 020 UR152 Pérou