%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Trinel, M.
%A Le Lamer, A. C.
%A Jullian, Valérie
%A Jacquemin, D.
%A Graton, J.
%A Cristofoli, V.
%A Crossay, E.
%A Yassine, M.
%A Rolland, C.
%A Vergnolle, N.
%A Mejia, K.
%A Cabanillas, B. J.
%A Racaud-Sultan, C.
%A Fabre, N.
%T Daphnanes diterpenes from the latex of Hura crepitans L. and activity against human colorectal cancer cells Caco-2
%D 2020
%L fdi:010079802
%G ENG
%J Bioorganic Chemistry
%@ 0045-2068
%K Hura crepitans ; Daphnane diterpenes ; Colorectal cancer ; Cytotoxicity ; Epithelial morphogenesis
%M ISI:000575793100009
%P 104132 [13 ]
%R 10.1016/j.bioorg.2020.104132
%U https://www.documentation.ird.fr/hor/fdi:010079802
%> https://www.documentation.ird.fr/intranet/publi/2020/10/010079802.pdf
%V 103
%W Horizon (IRD)
%X Hura crepitans (Euphorbiaceae) is a tree from South America that produces an irritant latex used as a fish poison. A bio-guided fractionation of an ethanolic extract of the latex led to the isolation and structural identification of three known daphnane-type diterpenes (1-3) including huratoxin (1), together with two new analogs (4, 5). Compound 1 was found to exhibit significant and selective cell growth inhibition against the colorectal cancer cell line Caco-2, with morphological modifications suggesting formations mimicking the intestinal crypt architecture. The underlying mechanism of 1 was further investigated, in comparison with 12-O-tetradecanoylphorbol-13-acetate (TPA), revealing two different mechanisms.
%$ 050 ; 076 ; 020