Daphnanes diterpenes from the latex of Hura crepitans L. and activity against human colorectal cancer cells Caco-2 Trinel, M. Le Lamer, A. C. /Jullian, Valérie Jacquemin, D. Graton, J. Cristofoli, V. Crossay, E. Yassine, M. Rolland, C. Vergnolle, N. Mejia, K. Cabanillas, B. J. Racaud-Sultan, C. Fabre, N. Hura crepitans Daphnane diterpenes Colorectal cancer Cytotoxicity Epithelial morphogenesis Hura crepitans (Euphorbiaceae) is a tree from South America that produces an irritant latex used as a fish poison. A bio-guided fractionation of an ethanolic extract of the latex led to the isolation and structural identification of three known daphnane-type diterpenes (1-3) including huratoxin (1), together with two new analogs (4, 5). Compound 1 was found to exhibit significant and selective cell growth inhibition against the colorectal cancer cell line Caco-2, with morphological modifications suggesting formations mimicking the intestinal crypt architecture. The underlying mechanism of 1 was further investigated, in comparison with 12-O-tetradecanoylphorbol-13-acetate (TPA), revealing two different mechanisms. 2020 text https://www.documentation.ird.fr/hor/fdi:010079802 fdi:010079802 Trinel M., Le Lamer A. C., Jullian Valérie, Jacquemin D., Graton J., Cristofoli V., Crossay E., Yassine M., Rolland C., Vergnolle N., Mejia K., Cabanillas B. J., Racaud-Sultan C., Fabre N.. Daphnanes diterpenes from the latex of Hura crepitans L. and activity against human colorectal cancer cells Caco-2. 2020, 103, 104132 [13 ] EN