@article{fdi:010079802,
  title = {{D}aphnanes diterpenes from the latex of {H}ura crepitans {L}. and activity against human colorectal cancer cells {C}aco-2},
  author = {{T}rinel, {M}. and {L}e {L}amer, {A}. {C}. and {J}ullian, {V}al{\'e}rie and {J}acquemin, {D}. and {G}raton, {J}. and {C}ristofoli, {V}. and {C}rossay, {E}. and {Y}assine, {M}. and {R}olland, {C}. and {V}ergnolle, {N}. and {M}ejia, {K}. and {C}abanillas, {B}. {J}. and {R}acaud-{S}ultan, {C}. and {F}abre, {N}.},
  editor = {},
  language = {{ENG}},
  abstract = {{H}ura crepitans ({E}uphorbiaceae) is a tree from {S}outh {A}merica that produces an irritant latex used as a fish poison. {A} bio-guided fractionation of an ethanolic extract of the latex led to the isolation and structural identification of three known daphnane-type diterpenes (1-3) including huratoxin (1), together with two new analogs (4, 5). {C}ompound 1 was found to exhibit significant and selective cell growth inhibition against the colorectal cancer cell line {C}aco-2, with morphological modifications suggesting formations mimicking the intestinal crypt architecture. {T}he underlying mechanism of 1 was further investigated, in comparison with 12-{O}-tetradecanoylphorbol-13-acetate ({TPA}), revealing two different mechanisms.},
  keywords = {{H}ura crepitans ; {D}aphnane diterpenes ; {C}olorectal cancer ; {C}ytotoxicity ; {E}pithelial morphogenesis},
  booktitle = {},
  journal = {{B}ioorganic {C}hemistry},
  volume = {103},
  numero = {},
  pages = {104132 [13 ]},
  ISSN = {0045-2068},
  year = {2020},
  DOI = {10.1016/j.bioorg.2020.104132},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079802},
}