Guerrero D. auteur aut IRD Cantaert T. auteur aut IRD Missé Dorothée auteur aut IRD text journalArticle eng text/pdf reformatted digital access Vector-borne diseases are responsible for over a billion infections each year and nearly one million deaths. Mosquito-borne dengue virus, West Nile, Japanese encephalitis, Zika, Chikungunya, and Rift Valley Fever viruses constitute major public health problems in regions with high densities of arthropod vectors. During the initial step of the transmission cycle, vector, host, and virus converge at the bite site, where local immune cells interact with the vector's saliva. Hematophagous mosquito saliva is a mixture of bioactive components known to modulate vertebrate hemostasis, immunity, and inflammation during the insect's feeding process. The capacity of mosquito saliva to modulate the host immune response has been well-studied over the last few decades and has led to the consensus that the presence of saliva is linked to the enhancement of virus transmission, host susceptibility, disease progression, viremia levels, and mortality. We review some of the major aspects of the interactions between mosquito saliva and the host immune response that may be useful for future studies on the control of arboviruses. specialized arbovirus mosquito saliva immune response saliva composition Aedes spp 052 050 10 407 [11] 2020 2235-2988 https://www.documentation.ird.fr/hor/fdi:010079564 10.3389/fcimb.2020.00407 2235-2988 [F B010079564] https://www.documentation.ird.fr/hor/fdi:010079564 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-09/010079564.pdf IRD - Base Horizon / Pleins textes 2020-10-09 2025-02-24 fdi:010079564 fre