@article{fdi:010079551,
  title = {{H}igh levels of genetic diversity within nilo-saharan populations : implications for human adaptation},
  author = {{M}ulindwa, {J}. and {N}oyes, {H}. and {I}lboudo, {H}. and {P}agani, {L}. and {N}yangiri, {O}. and {K}imuda, {M}. {P}. and {A}houty, {B}. and {A}sina, {O}. {F}. and {O}fon, {E}. and {K}amoto, {K}. and {K}abore, {J}. {W}. and {K}offi, {M}. and {N}goyi, {D}. {M}. and {S}imo, {G}. and {C}hisi, {J}. and {S}idibe, {I}. and {E}nyaru, {J}. and {S}imuunza, {M}. and {A}libu, {P}. and {J}amonneau, {V}incent and {C}amara, {M}. and {T}ait, {A}. and {H}all, {N}. and {B}ucheton, {B}runo and {M}ac{L}eod, {A}. and {H}ertz-{F}owler, {C}. and {M}atovu, {E}. and {T}rypano{GEN} {R}esearch {G}roup of the {H}3{A}frica {C}onsortium,},
  editor = {},
  language = {{ENG}},
  abstract = {{A}frica contains more human genetic variation than any other continent, but the majority of the population-scale analyses of the {A}frican peoples have focused on just two of the four major linguistic groups, the {N}iger-{C}ongo and {A}fro-{A}siatic, leaving the {N}ilo-{S}aharan and {K}hoisan populations under-represented. {I}n order to assess genetic variation and signatures of selection within a {N}ilo-{S}aharan population and between the {N}ilo-{S}aharan and {N}iger-{C}ongo and {A}fro-{A}siatic, we sequenced 50 genomes from the {N}ilo-{S}aharan {L}ugbara population of {N}orth-{W}est {U}ganda and 250 genomes from 6 previously unsequenced {N}iger-{C}ongo populations. {W}e compared these data to data from a further 16 {E}urasian and {A}frican populations including the {G}umuz, another putative {N}ilo-{S}aharan population from {E}thiopia. {O}f the 21 million variants identified in the {N}ilo-{S}aharan population, 3.57 million (17%) were not represented in db{SNP} and included predicted non-synonymous mutations with possible phenotypic effects. {W}e found greater genetic differentiation between the {N}ilo-{S}aharan {L}ugbara and {G}umuz populations than between any two {A}fro-{A}siatic or {N}iger-{C}ongo populations. {F}3 tests showed that {G}umuz contributed a genetic component to most {N}iger-{C}ongo {B} populations whereas {L}ugabara did not. {W}e scanned the genomes of the {L}ugbara for evidence of selective sweeps. {W}e found selective sweeps at four loci ({SLC}24{A}5, {SNX}13, {TYRP}1, and {UVRAG}) associated with skin pigmentation, three of which already have been reported to be under selection. {T}hese selective sweeps point toward adaptations to the intense {UV} radiation of the {S}ahel.},
  keywords = {{GUINEE} ; {COTE} {D}’{IVOIRE} ; {CAMEROUN} ; {REPUBLIQUE} {DEMOCRATIQUE} {DU} {CONGO} ; {ZAMBIA} ; {OUGANDA} ; {GAMBIA} ; {SIERRA}-{LEONE} ; {NIGERIA} ; {KENYA} ; {EGYPTE} ; {ETHIOPIE}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {H}uman {G}enetics},
  volume = {107},
  numero = {3},
  pages = {473--486},
  ISSN = {0002-9297},
  year = {2020},
  DOI = {10.1016/j.ajhg.2020.07.007},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079551},
}