@article{fdi:010079548,
  title = {{I}n vitro screening of a {FDA} approved chemical library reveals potential inhibitors of {SARS}-{C}o{V}-2 replication},
  author = {{T}ouret, {F}. and {G}illes, {M}agali and {B}arral, {K}. and {N}ougairede, {A}. and van {H}elden, {J}. and {D}ecroly, {E}. and {L}amballerie, {X}. de and {C}outard, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A} novel coronavirus, named {SARS}-{C}o{V}-2, emerged in 2019 in {C}hina and rapidly spread worldwide. {A}s no approved therapeutics exists to treat {COVID}-19, the disease associated to {SARS}-{C}ov-2, there is an urgent need to propose molecules that could quickly enter into clinics. {R}epurposing of approved drugs is a strategy that can bypass the time-consuming stages of drug development. {I}n this study, we screened the {PRESTWICK} {CHEMICAL} {LIBRARY} composed of 1,520 approved drugs in an infected cell-based assay. {T}he robustness of the screen was assessed by the identification of drugs that already demonstrated in vitro antiviral effect against {SARS}-{C}o{V}-2. {T}hereby, 90 compounds were identified as positive hits from the screen and were grouped according to their chemical composition and their known therapeutic effect. {T}hen {EC}50 and {CC}50 were determined for a subset of 15 compounds from a panel of 23 selected drugs covering the different groups. {E}leven compounds such as macrolides antibiotics, proton pump inhibitors, antiarrhythmic agents or {CNS} drugs emerged showing antiviral potency with 2<{EC}50<less than or equal to>20 mu {M}. {B}y providing new information on molecules inhibiting {SARS}-{C}o{V}-2 replication in vitro, this study provides information for the selection of drugs to be further validated in vivo. {D}isclaimer: {T}his study corresponds to the early stages of antiviral development and the results do not support by themselves the use of the selected drugs to treat {SARS}-{C}o{V}-2 infection.},
  keywords = {},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {10},
  numero = {1},
  pages = {13093 [8 ]},
  ISSN = {2045-2322},
  year = {2020},
  DOI = {10.1038/s41598-020-70143-6},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079548},
}