@article{fdi:010079488,
  title = {{S}patial epidemiology of {J}apanese encephalitis virus and other infections of the central nervous system infections in {L}ao {PDR} (2003-2011) : a retrospective analysis},
  author = {{R}attanavong, {S}. and {D}ubot {P}{\'e}r{\`e}s, {A}udrey and {M}ayxay, {M}. and {V}ongsouvath, {M}. and {L}ee, {S}. {J}. and {C}appelle, {J}. and {N}ewton, {P}. {N}. and {P}arker, {D}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {C}entral nervous system ({CNS}) infections are important contributors to morbidity and mortality and the causative agents for similar to 50% patients are never identified. {T}he causative agents of some {CNS} infections have distinct spatial and temporal patterns. {M}ethodology/{P}rincipal findings {H}ere we present the results of a spatial epidemiological and ecological analysis of {CNS} infections in {L}ao {PDR} (2003-2011). {T}he data came from hospitalizations for suspected {CNS} infection at {M}ahosot {H}ospital in {V}ientiane. {O}ut of 1,065 patients, 450 were assigned a confirmed diagnosis. {W}hile many communities in {L}ao {PDR} are in rural and remote locations, most patients in these data came from villages along major roads. {J}apanese encephalitis virus (({JEV}); n = 94) and {C}ryptococcus spp. (n = 70) were the most common infections. {JEV} infections peaked in the rainy season and {JEV} patients came from villages with higher surface flooding during the same month as admission. {JEV} infections were spatially dispersed throughout rural areas and were most common in children. {C}ryptococcus spp. infections clustered near {V}ientiane (an urban area) and among adults. {C}onclusions/{S}ignificance {T}he spatial and temporal patterns identified in this analysis are related to complex environmental, social, and geographic factors. {F}or example, {JEV} infected patients came from locations with environmental conditions (surface water) that are suitable to support larger mosquito vector populations. {M}ost patients in these data came from villages that are near major roads; likely the result of geographic and financial access to healthcare and also indicating that {CNS} diseases are underestimated in the region (especially from more remote areas). {A}s {L}ao {PDR} is undergoing major developmental and environmental changes, the space-time distributions of the causative agents of {CNS} infection will also likely change. {T}here is a major need for increased diagnostic abilities; increased access to healthcare, especially for rural populations; and for increased surveillance throughout the nation.},
  keywords = {{LAOS}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {14},
  numero = {5},
  pages = {art. e0008333 [18 ]},
  ISSN = {1935-2735},
  year = {2020},
  DOI = {10.1371/journal.pntd.0008333},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079488},
}