@article{fdi:010079478,
  title = {{A}lsinol, an arylamino alcohol derivative active against {P}lasmodium, {B}abesia, {T}rypanosoma, and {L}eishmania : past and new outcomes},
  author = {{A}rias, {M}. {H}. and {Q}uiliano, {M}. and {B}ourgeade-{D}elmas, {S}andra and {F}abing, {I}. and {C}hantal, {I}. and {B}erthier, {D}. and {M}inet, {C}. and {E}parvier, {V}. and {S}orres, {J}. and {S}tien, {D}. and {G}aliano, {S}. and {A}ldana, {I}. and {V}alentin, {A}. and {G}aravito, {G}. and {D}eharo, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alaria, babesiosis, trypanosomosis, and leishmaniasis are some of the most life-threatening parasites, but the range of drugs to treat them is limited. {A}n effective, safe, and low-cost drug with a large activity spectrum is urgently needed. {F}or this purpose, an aryl amino alcohol derivative called {A}lsinol was resynthesized, screened in silico, and tested against {P}lasmodium, {B}abesia, {T}rypanosoma, and {L}eishmania. {I}n silico {A}lsinol follows the {L}ipinski and {G}hose rules. {I}n vitro it had schizontocidal activity against {P}lasmodium falciparum and was able to inhibit gametocytogenesis; it was particularly active against late gametocytes. {I}n malaria-infected mice, it showed a dose-dependent activity similar to chloroquine. {I}t demonstrated a similar level of activity to reference compounds against{B}abesia divergens, and against promastigotes, and amastigotes stages of {L}eishmania in vitro. {I}t inhibited the in vitro growth of two {A}frican animal strains of {T}rypanosoma but was ineffective in vivo in our experimental conditions. {I}t showed moderate toxicity in {J}774{A}1 and {V}ero cell models. {T}he study demonstrated that {A}lsinol has a large spectrum of activity and is potentially affordable to produce. {N}evertheless, challenges remain in the process of scaling up synthesis, creating a suitable clinical formulation, and determining the safety margin in preclinical models.},
  keywords = {{A}ntiprotozoan ; {A}lsinol ; {B}abesia ; {L}eishmania ; {P}lasmodium falciparum gametocytes ; {T}rypanosoma},
  booktitle = {},
  journal = {{P}arasitology {R}esearch},
  volume = {119},
  numero = {10},
  pages = {3503--3515},
  ISSN = {0932-0113},
  year = {2020},
  DOI = {10.1007/s00436-020-06832-y},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079478},
}