@article{fdi:010079390,
  title = {{W}ide cross-species {RNA}-{S}eq comparison reveals convergent molecular mechanisms involved in nickel hyperaccumulation across dicotyledons},
  author = {{G}arcia de la {T}orre, {V}. {S}. and {M}ajorel {L}oulergue, {C}larisse and {R}igaill, {G}. {J}. and {A}lfonso-{G}onzalez, {D}. and {S}oubigou-{T}aconnat, {L}. and {P}illon, {Y}ohan and {B}arreau, {L}. and {T}homine, {S}. and {F}ogliani, {B}. and {B}urtet-{S}arramegna, {V}. and {M}erlot, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {A}nthropocene epoch is associated with the spreading of metals in the environment increasing oxidative and genotoxic stress on organisms. {I}nterestingly,c. 520 plant species growing on metalliferous soils acquired the capacity to accumulate and tolerate a tremendous amount of nickel in their shoots. {T}he wide phylogenetic distribution of these species suggests that nickel hyperaccumulation evolved multiple times independently. {H}owever, the exact nature of these mechanisms and whether they have been recruited convergently in distant species is not known. {T}o address these questions, we have developed a cross-species {RNA}-{S}eq approach combining differential gene expression analysis and cluster of orthologous group annotation to identify genes linked to nickel hyperaccumulation in distant plant families. {O}ur analysis reveals candidate orthologous genes encoding convergent function involved in nickel hyperaccumulation, including the biosynthesis of specialized metabolites and cell wall organization. {O}ur data also point out that the high expression of {IREG}/{F}erroportin transporters recurrently emerged as a mechanism involved in nickel hyperaccumulation in plants. {W}e further provide genetic evidence in the hyperaccumulator{N}occaea caerulescensfor the role of the {N}c{IREG}2 transporter in nickel sequestration in vacuoles. {O}ur results provide molecular tools to better understand the mechanisms of nickel hyperaccumulation and study their evolution in plants.},
  keywords = {convergence ; hyperaccumulator ; {IREG} ; {F}erroportin ; metal ; nickel ; {N}occaea ; caerulescens ; {RNA}-{S}eq ; {NOUVELLE} {CALEDONIE} ; {CUBA} ; {FRANCE}},
  booktitle = {},
  journal = {{N}ew {P}hytologist},
  volume = {229},
  numero = {2},
  pages = {994--1006},
  ISSN = {0028-646{X}},
  year = {2021},
  DOI = {10.1111/nph.16775},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079390},
}