@article{fdi:010079384,
  title = {{A}denovirus infections in {A}frican humans and wild non-human primates : great diversity and cross-species transmission},
  author = {{M}edkour, {H}. and {A}mona, {I}. and {A}kiana, {J}. and {D}avoust, {B}. and {B}itam, {I}. and {L}evasseur, {A}. and {T}all, {M}. {L}. and {D}iatta, {G}eorges and {S}okhna, {C}heikh and {H}ernandez-{A}guilar, {R}. {A}. and {B}arciela, {A}. and {G}orsane, {S}. and {L}a {S}cola, {B}. and {R}aoult, {D}. and {F}enollar, {F}. and {M}ediannikov, {O}leg},
  editor = {},
  language = {{ENG}},
  abstract = {{N}on-human primates ({NHP}s) are known hosts for adenoviruses ({A}d{V}s), so there is the possibility of the zoonotic or cross-species transmission of {A}d{V}s. {A}s with humans, {A}d{V} infections in animals can cause diseases that range from asymptomatic to fatal. {T}he aim of this study was to investigate the occurrence and diversity of {A}d{V}s in: (i) fecal samples of apes and monkeys from different {A}frican countries ({R}epublic of {C}ongo, {S}enegal, {D}jibouti and {A}lgeria), (ii) stool of humans living near gorillas in the {R}epublic of {C}ongo, in order to explore the potential zoonotic risks. {S}amples were screened by real-time and standard {PCR}s, followed by the sequencing of the partial {DNA} polymerase gene in order to identify the {A}d{V} species. {T}he prevalence was 3.3 folds higher in {NHP}s than in humans. {M}ore than 1/3 (35.8%) of the {NHP}s and 1/10 (10.5%) of the humans excreted {A}d{V}s in their feces. {T}he positive rate was high in great apes (46%), with a maximum of 54.2% in chimpanzees ({P}an troglodytes) and 35.9% in gorillas ({G}orilla gorilla), followed by monkeys (25.6%), with 27.5% in {B}arbary macaques ({M}acaca sylvanus) and 23.1% in baboons (seven{P}apio papioand six{P}apio hamadryas). {N}o green monkeys ({C}hlorocebus sabaeus) were found to be positive for {A}d{V}s. {T}he {A}d{V}s detected in {NHP}s were members of{H}uman mastadenovirus {E}({HA}d{V}-{E}), {HA}d{V}-{C} or {HA}d{V}-{B}, and those in the humans belonged to {HA}d{V}-{C} or {HA}d{V}-{D}. {HA}d{V}-{C} members were detected in both gorillas and humans, with evidence of zoonotic transmission since phylogenetic analysis revealed that gorilla {A}d{V}s belonging to {HA}d{V}-{C} were genetically identical to strains detected in humans who had been living around gorillas, and, inversely, a {HA}d{V}-{C} member {HA}d{V} type was detected in gorillas. {T}his confirms the gorilla-to-human transmission of adenovirus. which has been reported previously. {I}n addition, {HA}d{V}-{E} members, the most often detected here, are widely distributed among {NHP} species regardless of their origin, i.e., {HA}d{V}-{E} members seem to lack host specificity. {V}irus isolation was successful from a human sample and the strain of the {M}bo024 genome, of 35 kb, that was identified as belonging to {HA}d{V}-{D}, exhibited close identity to {HA}d{V}-{D} members for all genes. {T}his study provides information on the {A}d{V}s that infect {A}frican {NHP}s and the human populations living nearby, with an evident zoonotic transmission. {I}t is likely that {A}d{V}s crossed the species barrier between different {NHP} species (especially {HA}d{V}-{E} members), between {NHP}s and humans (especially {HA}d{V}-{C}), but also between humans, {NHP}s and other animal species.},
  keywords = {adenoviruses ; non-human primates ; humans ; prevalence ; {A}frica ; zoonotic diseases ; cross-species transmission ; {CONGO} ; {SENEGAL} ; {DJIBOUTI} ; {ALGERIE}},
  booktitle = {},
  journal = {{V}iruses},
  volume = {12},
  numero = {6},
  pages = {657 [14 ]},
  year = {2020},
  DOI = {10.3390/v12060657},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079384},
}