@article{fdi:010079316,
  title = {{T}he role of innate immunity in the protection conferred by a bacterial infection against cancer : study of an invertebrate model},
  author = {{J}acqueline, {C}. and {P}arvy, {J}. {P}. and {R}ollin, {M}. {L}. and {F}augere, {D}. and {R}enaud, {F}. and {M}iss{\'e}, {D}oroth{\'e}e and {T}homas, {F}. and {R}oche, {B}enjamin},
  editor = {},
  language = {{ENG}},
  abstract = {{A}ll multicellular organisms are exposed to a diversity of infectious agents and to the emergence and proliferation of malignant cells. {T}he protection conferred by some infections against cancer has been recently linked to the production of acquired immunity effectors such as antibodies. {H}owever, the evolution of innate immunity as a mechanism to prevent cancer and how it is jeopardized by infections remain poorly investigated. {H}ere, we explored this question by performing experimental infections in two genetically modified invertebrate models ({D}rosophila melanogaster) that develop invasive or non-invasive neoplastic brain tumors. {A}fter quantifying tumor size and antimicrobial peptide gene expression, we found that {D}rosophila larvae infected with a naturally occurring bacterium had smaller tumors compared to controls and to fungus-infected larvae. {T}his was associated with the upregulation of genes encoding two antimicrobial peptides-diptericin and drosomycin-that are known to be important mediators of tumor cell death. {W}e further confirmed that tumor regression upon infection was associated with an increase in tumor cell death. {T}hus, our study suggests that infection could have a protective role through the production of antimicrobial peptides that increase tumor cell death. {F}inally, our study highlights the need to understand the role of innate immune effectors in the complex interactions between infections and cancer cell communities in order to develop innovative cancer treatment strategies.},
  keywords = {},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {10},
  numero = {1},
  pages = {art. 10106 [8 p.]},
  ISSN = {2045-2322},
  year = {2020},
  DOI = {10.1038/s41598-020-66813-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079316},
}