@article{fdi:010079268,
  title = {{F}ibrosis in human adipose tissue : composition, distribution, and link with lipid metabolism and fat mass loss [plus {A}ppendix : {E}xperimental procedures and results]},
  author = {{D}ivoux, {A}. and {T}ordjman, {J}. and {L}acasa, {D}. and {V}eyrie, {N}. and {H}ugol, {D}. and {A}issat, {A}. and {B}asdevant, {A}. and {G}uerre-{M}illo, {M}. and {P}oitou, {C}. and {Z}ucker, {J}ean-{D}aniel and {B}edossa, {P}. and {C}l{\'e}ment, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective : {F}ibrosis is a newly appreciated hallmark of the pathological alteration of human white adipose tissue ({WAT}). {W}e investigated the composition of subcutaneous (sc{WAT}) and omental {WAT} (o{WAT}) fibrosis in obesity and its relationship with metabolic alterations and surgery-induced weight loss. {R}esearch design and methods : {S}urgical biopsies for sc{WAT} and o{WAT} were obtained in 65 obese ({BMI} 48.2 ± 0.8 kg/m(2)) and 9 lean subjects ({BMI} 22.8 ± 0.7 kg/m(2)). {O}bese subjects who were candidates for bariatric surgery were clinically characterized before, 3, 6, and 12 months after surgery, including fat mass evaluation by dual energy {X}-ray absorptiometry. {WAT} fibrosis was quantified and characterized using quantitative {PCR}, microscopic observation, and immunohistochemistry. {R}esults : {F}ibrosis amount, distribution and collagen types ({I}, {III}, and {VI}) present distinct characteristics in lean and obese subjects and with {WAT} depots localization (subcutaneous or omental). {O}bese subjects had more total fibrosis in o{WAT} and had more pericellular fibrosis around adipocytes than lean subjects in both depots. {M}acrophages and mastocytes were highly represented in fibrotic bundles in o{WAT}, whereas sc{WAT} was more frequently characterized by hypocellular fibrosis. {T}he o{WAT} fibrosis negatively correlated with omental adipocyte diameters ({R} = -0.30, {P} = 0.02), and with triglyceride levels ({R} = -0.42, {P} < 0.01), and positively with apo{A}1 ({R} = 0.25, {P} = 0.05). {I}mportantly, sc{WAT} fibrosis correlated negatively with fat mass loss measured at the three time points after surgery. {C}onclusions : {O}ur data suggest differential clinical consequences of fibrosis in human {WAT}. {I}n o{WAT}, fibrosis could contribute to limit adipocyte hypertrophy and is associated with a better lipid profile, whereas sc{WAT} fibrosis may hamper fat mass loss induced by surgery.},
  keywords = {{FRANCE}},
  booktitle = {},
  journal = {{D}iabetes},
  volume = {59},
  numero = {11},
  pages = {2817--2825 [+ 4 p.]},
  ISSN = {0012-1797},
  year = {2010},
  DOI = {10.2337/db10-0585},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079268},
}