Makinson A. auteur aut IRD Dubois J. auteur aut IRD Eymard-Duvernay Sabrina auteur aut IRD Leclercq P. auteur aut IRD Zaegel-Faucher O. auteur aut IRD Bernard L. auteur aut IRD Vassallo M. auteur aut IRD Barbuat C. auteur aut IRD Gény C. auteur aut IRD Thouvenot E. auteur aut IRD Costagliola D. auteur aut IRD Ozguler A. auteur aut IRD Zins M. auteur aut IRD Simony M. auteur aut IRD Reynes J. auteur aut IRD Berr C. auteur aut IRD text journalArticle eng text/pdf born digital access Background.There are limited data on the comparative prevalence of neurocognitive impairment (NCI) in aging people living with human immunodeficiency virus (PLHIV) and people not living with HIV. Methods.This was a cross-sectional study of PLHIV randomly matched by age (±4 years), gender, and education with 5 HIV-uninfected individuals from the CONSTANCES cohort. PLHIV were fluent in French and sequentially included during routine outpatient visits if aged 55-70 years, with HIV viral load <50 copies/mL, and lymphocyte T-CD4 level >-200 cells/uL in the past 24 and 12 months, respectively. The primary outcome was NCI as defined by the Frascati criteria. Multivariate normative comparison (MNC) and -1.5 standard deviations in >-2 neurocognitive domains were secondary outcomes of NCI. Results.Two hundred PLHIV were matched with 1000 controls. Median age was 62 years, and 85% were men. In PLHIV, the median T-CD4 lymphocyte level was 650 cells/uL, and median nadir T-CD4 lymphocyte level was 176 cells/uL. NCI was found in 71 (35.5%) PLHIV and in 242 (24.2%) controls (odds ratio [OR], 1.74; 95% confidence interval [CI], 1.25, 2.41). After adjusting for confounders, HIV remained significantly associated with NCI (OR, 1.50; 95% CI, 1.04, 2.16). Adjusted results were similar with NCI defined by MNC (ORMNC, 2.95; 95% CI, 1.13, 3.50) or -1.5 SD (OR-1.5, 2.24; 95% CI, 1.39, 3.62). Conclusions.In this matched study of aging individuals, HIV was significantly associated with an increased risk of NCI after adjusting for major confounders. Results were confirmed with more stringent NCI classifications. specialized FRANCE 050 052 70 12 2641-2648 2020 1058-4838 https://www.documentation.ird.fr/hor/fdi:010079229 10.1093/cid/ciz670 1058-4838 [F B010079229] https://www.documentation.ird.fr/hor/fdi:010079229 https://www.documentation.ird.fr/intranet/publi/depot/2020-06-26/010079229.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2020-06-18 2025-02-24 fdi:010079229 fre