Demontès M. auteur aut IRD Eymard-Duvernay Sabrina auteur aut IRD Allavena C. auteur aut IRD Jovelin T. auteur aut IRD Reynes J. auteur aut IRD Hentzien M. auteur aut IRD Ravaux I. auteur aut IRD Delobel P. auteur aut IRD Bregigeon S. auteur aut IRD Rey D. auteur aut IRD Ferry T. auteur aut IRD Gagneux-Brunon A. auteur aut IRD Robineau O. auteur aut IRD Pugliese P. auteur aut IRD Duvivier C. auteur aut IRD Cabié A. auteur aut IRD Chirouze C. auteur aut IRD Jacomet C. auteur aut IRD Lamaury I. auteur aut IRD Merrien D. auteur aut IRD Hoen B. auteur aut IRD Hocqueloux L. auteur aut IRD Cheret A. auteur aut IRD Katlama C. auteur aut IRD Arvieux C. auteur aut IRD Krolak-Salmon P. auteur aut IRD Makinson A. auteur aut IRD Delaporte Eric auteur aut IRD et al. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Background : We assessed prevalence of multimorbidity (MM) according to year of human immunodeficiency virus (HIV) diagnosis in elderly people living with HIV (PLWH). Methods : This was a cross-sectional study of MM in PLWH aged >-70 years from the Dat'AIDS French multicenter cohort. MM was defined as at least 3 coexistent morbidities of high blood pressure, diabetes mellitus, osteoporosis, non-AIDS cancer, chronic renal failure, cardiovascular and cerebrovascular disease, obesity, undernutrition, or hypercholesterolemia. Logistic regression models evaluated the association between MM and calendar periods of HIV diagnosis (1983-1996, 1997-2006, and 2007-2018). The secondary analysis evaluated MM as a continuous outcome, and a sensitivity analysis excluded PLWH with nadir CD4 count <200 cells/ul. Results : Between January 2017 and September 2018, 2476 PLWH were included. Median age was 73 years, 75% were men, median CD4 count was 578 cells/ul, and 94% had controlled viremia. MM prevalence was 71%. HBP and hypercholesterolemia were the most prevalent comorbidities. After adjustment for age, gender, smoking status, hepatitis C and hepatitis B virus coinfection, group of exposure, nadir CD4 count, CD4:CD8 ratio, and last CD4 level, calendar period of diagnosis was not associated with MM (P = .169). MM was associated with older age, CD4/CD8 ratio <0.8, and nadir CD4 count <200 cells/ul. Similar results were found with secondary and sensitivity analyses. Conclusions : MM prevalence was high and increased with age, low CD4/CD8 ratio, and nadir CD4 count <200 cells/ul but was not associated with calendar periods of HIV diagnosis. Known duration of HIV diagnosis does not seem to be a criterion for selecting elderly PLWH at risk of MM. specialized FRANCE 050 052 020 [Publ. online 2019/12/09] art. ciz1171 [9 ] 2020 1058-4838 https://www.documentation.ird.fr/hor/fdi:010079204 10.1093/cid/ciz1171 1058-4838 [F B010079204] https://www.documentation.ird.fr/hor/fdi:010079204 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-06/010079204.pdf IRD - Base Horizon / Pleins textes 2020-06-09 2025-02-24 fdi:010079204 fre