%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Demontès, M.
%A Eymard-Duvernay, Sabrina
%A Allavena, C.
%A Jovelin, T.
%A Reynes, J.
%A Hentzien, M.
%A Ravaux, I.
%A Delobel, P.
%A Bregigeon, S.
%A Rey, D.
%A Ferry, T.
%A Gagneux-Brunon, A.
%A Robineau, O.
%A Pugliese, P.
%A Duvivier, C.
%A Cabié, A.
%A Chirouze, C.
%A Jacomet, C.
%A Lamaury, I.
%A Merrien, D.
%A Hoen, B.
%A Hocqueloux, L.
%A Cheret, A.
%A Katlama, C.
%A Arvieux, C.
%A Krolak-Salmon, P.
%A Makinson, A.
%A Delaporte, Eric
%A et al.
%T Multimorbidity in elderly persons according to the year of diagnosis of human immunodeficiency virus infection : a cross-sectional dat’aids cohort study
%D 2020
%L fdi:010079204
%G ENG
%J Clinical Infectious Diseases
%@ 1058-4838
%K FRANCE
%M ISI:000607829500018
%P art. ciz1171 [9 ]
%R 10.1093/cid/ciz1171
%U https://www.documentation.ird.fr/hor/fdi:010079204
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-06/010079204.pdf
%V [Publ. online 2019/12/09]
%W Horizon (IRD)
%X Background : We assessed prevalence of multimorbidity (MM) according to year of human immunodeficiency virus (HIV) diagnosis in elderly people living with HIV (PLWH). Methods : This was a cross-sectional study of MM in PLWH aged >-70 years from the Dat'AIDS French multicenter cohort. MM was defined as at least 3 coexistent morbidities of high blood pressure, diabetes mellitus, osteoporosis, non-AIDS cancer, chronic renal failure, cardiovascular and cerebrovascular disease, obesity, undernutrition, or hypercholesterolemia. Logistic regression models evaluated the association between MM and calendar periods of HIV diagnosis (1983-1996, 1997-2006, and 2007-2018). The secondary analysis evaluated MM as a continuous outcome, and a sensitivity analysis excluded PLWH with nadir CD4 count <200 cells/ul. Results : Between January 2017 and September 2018, 2476 PLWH were included. Median age was 73 years, 75% were men, median CD4 count was 578 cells/ul, and 94% had controlled viremia. MM prevalence was 71%. HBP and hypercholesterolemia were the most prevalent comorbidities. After adjustment for age, gender, smoking status, hepatitis C and hepatitis B virus coinfection, group of exposure, nadir CD4 count, CD4:CD8 ratio, and last CD4 level, calendar period of diagnosis was not associated with MM (P = .169). MM was associated with older age, CD4/CD8 ratio <0.8, and nadir CD4 count <200 cells/ul. Similar results were found with secondary and sensitivity analyses. Conclusions : MM prevalence was high and increased with age, low CD4/CD8 ratio, and nadir CD4 count <200 cells/ul but was not associated with calendar periods of HIV diagnosis. Known duration of HIV diagnosis does not seem to be a criterion for selecting elderly PLWH at risk of MM.
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