@article{fdi:010079204,
  title = {{M}ultimorbidity in elderly persons according to the year of diagnosis of human immunodeficiency virus infection : a cross-sectional dat’aids cohort study},
  author = {{D}emont{\`e}s, {M}. and {E}ymard-{D}uvernay, {S}abrina and {A}llavena, {C}. and {J}ovelin, {T}. and {R}eynes, {J}. and {H}entzien, {M}. and {R}avaux, {I}. and {D}elobel, {P}. and {B}regigeon, {S}. and {R}ey, {D}. and {F}erry, {T}. and {G}agneux-{B}runon, {A}. and {R}obineau, {O}. and {P}ugliese, {P}. and {D}uvivier, {C}. and {C}abi{\'e}, {A}. and {C}hirouze, {C}. and {J}acomet, {C}. and {L}amaury, {I}. and {M}errien, {D}. and {H}oen, {B}. and {H}ocqueloux, {L}. and {C}heret, {A}. and {K}atlama, {C}. and {A}rvieux, {C}. and {K}rolak-{S}almon, {P}. and {M}akinson, {A}. and {D}elaporte, {E}ric and et al.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground : {W}e assessed prevalence of multimorbidity ({MM}) according to year of human immunodeficiency virus ({HIV}) diagnosis in elderly people living with {HIV} ({PLWH}). {M}ethods : {T}his was a cross-sectional study of {MM} in {PLWH} aged >-70 years from the {D}at'{AIDS} {F}rench multicenter cohort. {MM} was defined as at least 3 coexistent morbidities of high blood pressure, diabetes mellitus, osteoporosis, non-{AIDS} cancer, chronic renal failure, cardiovascular and cerebrovascular disease, obesity, undernutrition, or hypercholesterolemia. {L}ogistic regression models evaluated the association between {MM} and calendar periods of {HIV} diagnosis (1983-1996, 1997-2006, and 2007-2018). {T}he secondary analysis evaluated {MM} as a continuous outcome, and a sensitivity analysis excluded {PLWH} with nadir {CD}4 count <200 cells/ul. {R}esults : {B}etween {J}anuary 2017 and {S}eptember 2018, 2476 {PLWH} were included. {M}edian age was 73 years, 75% were men, median {CD}4 count was 578 cells/ul, and 94% had controlled viremia. {MM} prevalence was 71%. {HBP} and hypercholesterolemia were the most prevalent comorbidities. {A}fter adjustment for age, gender, smoking status, hepatitis {C} and hepatitis {B} virus coinfection, group of exposure, nadir {CD}4 count, {CD}4:{CD}8 ratio, and last {CD}4 level, calendar period of diagnosis was not associated with {MM} ({P} = .169). {MM} was associated with older age, {CD}4/{CD}8 ratio <0.8, and nadir {CD}4 count <200 cells/ul. {S}imilar results were found with secondary and sensitivity analyses. {C}onclusions : {MM} prevalence was high and increased with age, low {CD}4/{CD}8 ratio, and nadir {CD}4 count <200 cells/ul but was not associated with calendar periods of {HIV} diagnosis. {K}nown duration of {HIV} diagnosis does not seem to be a criterion for selecting elderly {PLWH} at risk of {MM}.},
  keywords = {{FRANCE}},
  booktitle = {},
  journal = {{C}linical {I}nfectious {D}iseases},
  volume = {[{P}ubl. online 2019/12/09]},
  numero = {},
  pages = {art. ciz1171 [9 ]},
  ISSN = {1058-4838},
  year = {2020},
  DOI = {10.1093/cid/ciz1171},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079204},
}