Moussiliou A. auteur aut IRD Turner L. auteur aut IRD Cottrell Gilles auteur aut IRD Doritchamou J. auteur aut IRD Gbedande K. auteur aut IRD Fievet Nadine auteur aut IRD Luty A. J. F. auteur aut IRD Massougbodji A. auteur aut IRD Theander T. G. auteur aut IRD Deloron Philippe auteur aut IRD Lavstsen T. auteur aut IRD Ndam N. T. auteur aut IRD text journalArticle eng text/pdf born digital access Background. Plasmodiumfalciparum-infected erythrocytes bind to specific endothelial cell receptors via members of the PfEMP1 family exported onto the erythrocyte surface. These interactions are mediated by different types of cysteine-rich interdomain region (CIDR) domains found in the N-terminal region of all PfEMP 1 . CIDR alpha 1 domains bind endothelial protein C receptor (EPCR), CIDR alpha 2-6 domains bind CD36, whereas the receptor specificity of CIDR beta/gamma/delta domains is unknown. Methods. In this study, we investigated the level of immunoglobulin (Ig)G targeting the different types of PfEMP1 CIDR during the first year of life. We used plasma collected longitudinally from children of pregnant women who had been followed closely through pregnancy. Results. Antibodies to CIDR alpha 1 domains were more frequent in cord blood compared with antibodies to CIDR alpha 2-6 domains. Higher IgG levels to EPCR-binding CIDR alpha 1 variants positively correlated with the timing of first infections. Antibodies to all PfEMP1 types declined at similar rates to the point of disappearance over the first 6 months of life. At 12 months, children had acquired antibody to all types of CIDR domains, mostly in children with documented P falciparum infections. Conclusions. These observations agree with the notion that the timing and phenotype of first P falciparum infections in life are influenced by the immune status of the mother. specialized children CIDR domains IgG malaria PfEMP 1 BENIN 052 050 221 12 2010-2017 2020 0022-1899 https://www.documentation.ird.fr/hor/fdi:010079150 10.1093/infdis/jiaa043 0022-1899 [F B010079150] https://www.documentation.ird.fr/hor/fdi:010079150 https://www.documentation.ird.fr/intranet/publi/2020/07/010079150.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2020-07-31 2020-07-31 fdi:010079150 fre