@article{fdi:010079150,
  title = {{D}ynamics of {P}f{EMP} 1 antibody profile from birth to 12 months of age in {B}eninese infants},
  author = {{M}oussiliou, {A}. and {T}urner, {L}. and {C}ottrell, {G}illes and {D}oritchamou, {J}. and {G}bedande, {K}. and {F}ievet, {N}adine and {L}uty, {A}. {J}. {F}. and {M}assougbodji, {A}. and {T}heander, {T}. {G}. and {D}eloron, {P}hilippe and {L}avstsen, {T}. and {N}dam, {N}. {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {P}lasmodiumfalciparum-infected erythrocytes bind to specific endothelial cell receptors via members of the {P}f{EMP}1 family exported onto the erythrocyte surface. {T}hese interactions are mediated by different types of cysteine-rich interdomain region ({CIDR}) domains found in the {N}-terminal region of all {P}f{EMP} 1 . {CIDR} alpha 1 domains bind endothelial protein {C} receptor ({EPCR}), {CIDR} alpha 2-6 domains bind {CD}36, whereas the receptor specificity of {CIDR} beta/gamma/delta domains is unknown. {M}ethods. {I}n this study, we investigated the level of immunoglobulin ({I}g){G} targeting the different types of {P}f{EMP}1 {CIDR} during the first year of life. {W}e used plasma collected longitudinally from children of pregnant women who had been followed closely through pregnancy. {R}esults. {A}ntibodies to {CIDR} alpha 1 domains were more frequent in cord blood compared with antibodies to {CIDR} alpha 2-6 domains. {H}igher {I}g{G} levels to {EPCR}-binding {CIDR} alpha 1 variants positively correlated with the timing of first infections. {A}ntibodies to all {P}f{EMP}1 types declined at similar rates to the point of disappearance over the first 6 months of life. {A}t 12 months, children had acquired antibody to all types of {CIDR} domains, mostly in children with documented {P} falciparum infections. {C}onclusions. {T}hese observations agree with the notion that the timing and phenotype of first {P} falciparum infections in life are influenced by the immune status of the mother.},
  keywords = {children ; {CIDR} domains ; {I}g{G} ; malaria ; {P}f{EMP} 1 ; {BENIN}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {221},
  numero = {12},
  pages = {2010--2017},
  ISSN = {0022-1899},
  year = {2020},
  DOI = {10.1093/infdis/jiaa043},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079150},
}