@article{fdi:010079028,
  title = {{I}ndividual and neighbourhood socioeconomic inequalities in cognitive impairment : cross-sectional findings from the {F}rench {CONSTANCES} cohort},
  author = {{L}etellier, {N}. and {C}arri{\`e}re, {I}. and {C}adot, {E}mmanuelle and {B}erkman, {L}. and {G}oldberg, {M}. and {Z}ins, {M}. and {B}err, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjectives {D}espite the recent awareness of the environment impact on brain ageing, the influence of the neighbourhood socioeconomic status on cognitive impairment remains unclear. {H}ere, we investigated the effects of individual and neighbourhood deprivation on cognitive impairment in middle-aged and young-old people. {D}esign {C}ross-sectional study. {S}ettings 21 {H}ealth {S}creening {C}entres in the entire {F}rench metropolitan territory. {P}articipants {A} total of 44 648 participants (age range: 45 to 69 years) from the {F}rench {CONSTANCES} cohort were included in the analyses. {M}ain outcomes {A}ssociations between the overall cognitive score (based on a standardised battery of cognitive tests administered by neuropsychologists) and individual deprivation ({E}valuation of {D}eprivation and {I}nequalities in {H}ealth {S}creening {C}entres; {EPICES} score) and geographical deprivation ({F}rench {D}eprivation {I}ndex; {FD}ep index). {R}esults {B}ased on the {EPICES} score (validated cut-off >= 30.17), 12% of participants were considered to be deprived. {A}fter mutual adjustment, individual and geographical deprivation were associated with higher cognitive impairment in a multilevel logistic regression analysis that was also adjusted for sociodemographic, lifestyle and health factors. {S}pecifically, individual deprivation was associated with an odds increase of 55% ({OR}=1.55, 95% {CI}: 1.45 to 1.66). {T}he risk of global cognitive impairment progressively increased with the neighbourhood deprivation level, evaluated by the {FD}ep index (reference {Q}1; {Q}2: {OR}=1.09, 95% {CI}: 0.98 to 1.20; {Q}3: {OR}=1.15, 95% {CI}: 1.04 to 1.27; {Q}4: {OR}=1.15, 95% {CI}: 1.04 to 1.28; {Q}5: {OR}=1.25, 95% {CI}: 1.13 to 1.39). {C}onclusion {O}ur results suggest that the neighbourhood socioeconomic deprivation level is associated with cognitive impairment, independently of the individual deprivation level. {A} better understanding of this association could help to define new prevention strategies to target high-risk residents and high-risk geographical areas in order to reduce social health inequalities.},
  keywords = {{FRANCE}},
  booktitle = {},
  journal = {{BMJ} {O}pen},
  volume = {10},
  numero = {3},
  pages = {e033751 [9 ]},
  ISSN = {2044-6055},
  year = {2020},
  DOI = {10.1136/bmjopen-2019-033751},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079028},
}