Di Ciaccio M. auteur aut IRD Sagaon Teyssier Luis auteur aut IRD Mimi M. auteur aut IRD Suzan-Monti M. auteur aut IRD Protiere C. auteur aut IRD Castro D. R. auteur aut IRD Meyer L. auteur aut IRD Tremblay C. auteur aut IRD Chidiac C. auteur aut IRD Capitant C. auteur aut IRD Preau M. auteur aut IRD Molina J. M. auteur aut IRD Spire B. auteur aut IRD ANRS IPERGAY Study Group auteur aut IRD text journalArticle eng text/pdf born digital access Pre-Exposure Prophylaxis (PrEP) is changing the landscape of HIV prevention, and may bring changes in sexual behaviors. The double-blind phase (DBP) and open-label extension (OLE) study of the ANRS-IPERGAY trial allowed us to assess changes in sexual behavior of men who have sex with men (MSM) taking sexual activity-based (i.e., on-demand) PrEP. Generalized Estimating Equation (GEE) models found a significant decrease in the number of sexual partners (Coefficient [CI95%], p value; - 0.37[- 0.70 to - 0.04], p = 0.03) between the DBP and OLE as well as in the number of sexual relations (- 0.25 [- 0.49 to 0.00], 0.04). GEE estimates also showed that respondents' most recent sexual relation was less likely to have been with an unknown casual partner during the OLE than during the DBP (Odds Ratio [CI95%], p value: 0.75[0.62-0.92], 0.005). Furthermore, they showed an increase in the proportion of condomless anal sex in the OLE (1.32[1.04-1.67], 0.02), a decrease in the proportion of 'suboptimal PrEP adherence' over time (0.75[0.58-0.97], p = 0.03), a decrease in PrEP only use (0.73[0.55-0.96], 0.03) and in both PrEP and condom use over time (0.70[0.51-0.95], 0.02) and finally, a decrease in alcohol consumption between the DBP and OLE (0.74[0.61-0.90], 0.002). We observed both protective and risky behaviors in terms of HIV and STI risk after on-demand PrEP uptake in the OLE phase. Our findings are consistent with results from previous PrEP trials. specialized HIV risk management PrEP Behaviors MSM ANRS-IPERGAY trial FRANCE CANADA 056 052 24 11 3093-3106 2020 1090-7165 https://www.documentation.ird.fr/hor/fdi:010078987 10.1007/s10461-020-02864-8 1090-7165 [F B010078987] https://www.documentation.ird.fr/hor/fdi:010078987 https://www.documentation.ird.fr/intranet/publi/depot/2021-04-20/010078987.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2020-06-09 2025-02-24 fdi:010078987 fre