@article{fdi:010078935,
  title = {{G}ut microbiota profile of obese diabetic women submitted to roux-en-y gastric bypass and its association with food intake and postoperative diabetes remission},
  author = {{A}l {A}ssal, {K}. and {P}rifti, {E}di and {B}elda, {E}. and {S}ala, {P}. and {C}lement, {K}. and {D}ao, {M}. {C}. and {D}ore, {J}. and {L}evenez, {F}. and {T}addei, {C}. {R}. and {F}onseca, {D}. {C}. and {R}ocha, {I}. {M}. and {B}almant, {B}. {D}. and {T}homas, {A}. {M}. and {S}anto, {M}. {A}. and {D}ias-{N}eto, {E}. and {S}etubal, {J}. {C}. and {Z}ucker, {J}ean-{D}aniel and {B}elarmino, {G}. and {T}orrinhas, {R}. {S}. and {W}aitzberg, {D}. {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{G}ut microbiota composition is influenced by environmental factors and has been shown to impact body metabolism. {O}bjective: {T}o assess the gut microbiota profile before and after {R}oux-en-{Y} gastric bypass ({RYGB}) and the correlation with food intake and postoperative type 2 diabetes remission ({T}2{D}r). {D}esign: {G}ut microbiota profile from obese diabetic women was evaluated before (n = 25) and 3 (n = 20) and 12 months (n = 14) after {RYGB}, using {M}i{S}eq {I}llumina-based {V}4 bacterial 16{S} r{RNA} gene profiling. {D}ata on food intake (7-day record) and {T}2{D}r ({A}merican {D}iabetes {A}ssociation ({ADA}) criteria) were recorded. {R}esults: {P}reoperatively, the abundance of five bacteria genera differed between patients with (57%) and without {T}2{D}r (p < 0.050). {P}reoperative gut bacteria genus signature was able to predict the {T}2{D}r status with 0.94 accuracy {ROC} curve (receiver operating characteristic curve). {P}ostoperatively (vs. preoperative), the relative abundance of some gut bacteria genera changed, the gut microbial richness increased, and the {F}irmicutes to {B}acteroidetes ratio (r{FB}) decreased (p < 0.05) regardless of {T}2{D}r. {R}ichness levels was correlated with dietary profile pre and postoperatively, mainly displaying positive and inverse correlations with fiber and lipid intakes, respectively (p < 0.05). {C}onclusions: {G}ut microbiota profile was influenced by {RYGB} and correlated with diet and {T}2{D}r preoperatively, suggesting the possibility to assess its composition to predict postoperative {T}2{D}r.},
  keywords = {bariatric surgery ; type 2 diabetes mellitus ; gut microbiota ; {BRESIL} ; {SAO} {PAULO}},
  booktitle = {},
  journal = {{N}utrients},
  volume = {12},
  numero = {2},
  pages = {art. 278 [18p.]},
  year = {2020},
  DOI = {10.3390/nu12020278},
  URL = {https://www.documentation.ird.fr/hor/fdi:010078935},
}