@article{fdi:010078894,
  title = {{I}mplications of asymptomatic infection for the natural history of selected parasitic tropical diseases},
  author = {{A}lvar, {J}. and {A}lves, {F}. and {B}ucheton, {B}runo and {B}urrows, {L}. and {B}uscher, {P}. and {C}arrillo, {E}. and {F}elger, {I}. and {H}ubner, {M}. {P}. and {M}oreno, {J}. and {P}inazo, {M}. {J}. and {R}ibeiro, {I}. and {S}osa-{E}stani, {S}. and {S}pecht, {S}. and {T}arral, {A}. and {W}ourgaft, {N}. {S}. and {B}ilbe, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}rogress has been made in the control or elimination of tropical diseases, with a significant reduction of incidence. {H}owever, there is a risk of re-emergence if the factors fueling transmission are not dealt with. {A}lthough it is essential to understand these underlying factors for each disease, asymptomatic carriers are a common element that may promote resurgence; their impact in terms of proportion in the population and role in transmission needs to be determined. {I}n this paper, we review the current evidence on whether or not to treat asymptomatic carriers given the relevance of their role in the transmission of a specific disease, the efficacy and toxicity of existing drugs, the {P}ublic {H}ealth interest, and the benefit at an individual level, for example, in {C}hagas disease, to prevent irreversible organ damage. {I}n the absence of other control tools such as vaccines, there is a need for safer drugs with good risk/benefit profiles in order to change the paradigm so that it addresses the complete infectious process beyond manifest disease to include treatment of non-symptomatic infected persons.},
  keywords = {{A}symptomatic ; {C}hagas disease ; {L}eishmaniasis ; {F}ilariasis ; {H}uman {A}frican trypanosomiasis ; {M}alaria ; {MONDE} ; {ZONE} {TROPICALE}},
  booktitle = {},
  journal = {{S}eminars in {I}mmunopathology},
  volume = {42},
  numero = {3},
  pages = {231--246},
  ISSN = {1863-2297},
  year = {2020},
  DOI = {10.1007/s00281-020-00796-y},
  URL = {https://www.documentation.ird.fr/hor/fdi:010078894},
}