@article{fdi:010078779,
  title = {{S}tructure and functionality in flavivirus {NS}-proteins : perspectives for drug design},
  author = {{B}ollati, {M}. and {A}lvarez, {K}. and {A}ssenberg, {R}. and {B}aronti, {C}ecile and {C}anard, {B}. and {C}ook, {S}. and {C}outard, {B}. and {D}ecroly, {E}. and de {L}amballerie, {X}avier and {G}ould, {E}. {A}. and {G}rard, {G}. and {G}rimes, {J}. {M}. and {H}ilgenfeld, {R}. and {J}ansson, {A}. {M}. and {M}alet, {H}. and {M}ancini, {E}. {J}. and {M}astrangelo, {E}. and {M}attevi, {A}. and {M}ilani, {M}. and {M}oureau, {G}r{\'e}gory and {N}eyts, {J}. and {O}wens, {R}. {J}. and {R}en, {J}. {S}. and {S}elisko, {B}. and {S}peroni, {S}. and {S}teuber, {H}. and {S}tuart, {D}. {I}. and {U}nge, {T}. and {B}olognesi, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{F}laviviridae are small enveloped viruses hosting a positive-sense single-stranded {RNA} genome. {B}esides yellow fever virus, a landmark case in the history of virology, members of the {F}lavivirus genus, such as {W}est {N}ile virus and dengue virus, are increasingly gaining attention due to their re-emergence and incidence in different areas of the world. {A}dditional environmental and demographic considerations suggest that novel or known flaviviruses will continue to emerge in the future. {N}evertheless, up to few years ago flaviviruses were considered low interest candidates for drug design. {A}t the start of the {E}uropean {U}nion {VIZIER} {P}roject, in 2004, just two crystal structures of protein domains from the flaviviral replication machinery were known. {S}uch pioneering studies, however, indicated the flaviviral replication complex as a promising target for the development of antiviral compounds. {H}ere we review structural and functional aspects emerging from the characterization of two main components ({NS}3 and {NS}5 proteins) of the flavivirus replication complex. {M}ost of the reviewed results were achieved within the {E}uropean {U}nion {VIZIER} {P}roject, and cover topics that span from viral genomics to structural biology and inhibition mechanisms. {T}he ultimate aim of the reported approaches is to shed light on the design and development of antiviral drug leads.},
  keywords = {{F}lavivirus ; {F}laviviral {NS}3 protein ; {F}laviviral {NS}5 protein ; {P}rotease ; {H}elicase ; {P}olymerase ; {M}ethyltransferase ; {F}lavivirus protein structure ; {A}ntivirals ; {VIZIER} {C}onsortium},
  booktitle = {},
  journal = {{A}ntiviral {R}esearch},
  volume = {87},
  numero = {2},
  pages = {125--148},
  ISSN = {0166-3542},
  year = {2010},
  DOI = {10.1016/j.antiviral.2009.11.009},
  URL = {https://www.documentation.ird.fr/hor/fdi:010078779},
}