@article{fdi:010078777,
  title = {{G}enomic and antigenic characterization of the newly emerging {C}hinese duck egg-drop syndrome flavivirus : genomic comparison with {T}embusu and {S}itiawan viruses},
  author = {{L}iu, {P}. {P}. and {L}u, {H}. and {L}i, {S}. and {M}oureau, {G}r{\'e}gory and {D}eng, {Y}. {Q}. and {W}ang, {Y}. {Y}. and {Z}hang, {L}. {J}. and {J}iang, {T}. and {D}e {L}amballerie, {X}avier and {Q}in, {C}. {F}. and {G}ould, {E}. {A}. and {S}u, {J}. {L}. and {G}ao, {G}. {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{D}uck egg-drop syndrome virus ({DEDSV}) is a newly emerging pathogenic flavivirus causing avian diseases in {C}hina. {T}he infection occurs in laying ducks characterized by a severe drop in egg production with a fatality rate of 5-15%. {T}he virus was found to be most closely related to {T}embusu virus ({TMUV}), an isolate from mosquitoes in {S}outh-east {A}sia {H}ere, we have sequenced and characterized the full-length genomes of seven {DEDSV} strains, including the 5'- and 3'-non-coding regions ({NCR}s). {W}e also report for the first time the {ORF} sequences of {TMUV} and {S}itiawan virus ({STWV}), another closely related flavivirus isolated from diseased chickens. {W}e analysed the phylogenetic and antigenic relationships of {DEDSV} in relation to the {A}sian viruses {TMUV} and {STWV}, and other representative flaviviruses. {O}ur results confirm the close relationship between {DEDSV} and {TMUV}/{STWV} and we discuss their probable evolutionary origins. {W}e have also characterized the cleavage sites, potential glycosylation sites and unique motifs/modules of these viruses. {A}dditionally, conserved sequences in both 5'- and 3'-{NCR}s were identified and the predicted secondary structures of the terminal sequences were studied. {A}ntigenic cross-reactivity comparisons of {DEDSV} with related pathogenic flaviviruses identified a surprisingly close relationship with dengue virus ({DENV}) and raised the question of whether or not {DEDSV} may have a potential infectious threat to man. {I}mportantly, {DEDSV} can be efficiently recognized by a broadly cross-reactive flavivirus m{A}b, 2{A}10{G}6, derived against {DENV}. {T}he significance of these studies is discussed in the context of the emergence, evolution, epidemiology, antigenicity and pathogenicity of the newly emergent {DEDSV}.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {G}eneral {V}irology},
  volume = {93},
  numero = {{P}art 10},
  pages = {2158--2170},
  ISSN = {0022-1317},
  year = {2012},
  DOI = {10.1099/vir.0.043554-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010078777},
}