Severson D.W. auteur aut IRD De Bruyn B. auteur aut IRD Lovin D.D. auteur aut IRD Brown S.E. auteur aut IRD Knudson D.L. auteur aut IRD Morlais Isabelle auteur aut IRD text journalArticle eng text/pdf reformatted digital access An in silico comparative genomics approach was used to identify putative orthologs to genetically mapped genes from the mosquito, Aedes aegypti, in the Drosophila melanogaster and Anopheles gambiae genome databases. Comparative chromosome positions of 73 D. melanogaster orthologs indicated significant deviations from a random distribution across each of the five A. aegypti chromosomal regions, suggesting that some ancestral chromosome elements have been conserved. However, the two genomes also reflect extensive reshuffling within and between chromosomal regions. Comparative chromosome positions of A. gambiae orthologs indicate unequivocally that A. aegypti chromosome regions share extensive homology to the five A. gambiae chromosome arms. Whole-arm or near-whole-arm homology was contradicted with only two genes among the 75 A. aegypti genes for which orthologs to A. gambiae were identified. The two genomes contain large conserved chromosome segments that generally correspond to break/fusion events and a reciprocal translocation with extensive paracentric inversions evident within. Only very tightly linked genes are likely to retain conserved linear orders within chromosome segments. The D. melanogaster and A. gambiae genome databases therefore offer limited potential for comparative positional gene determinations among even closely related dipterans, indicating the necessity for additional genome sequencing projects with other dipteran species. specialized FIEVRE JAUNE PALUDISME VECTEUR MOUSTIQUE GENETIQUE DE POPULATION LIAISON GENETIQUE BIOLOGIE MOLECULAIRE ETUDE COMPARATIVE GENOMIQUE 052ANOPAL 052CULARB 95 3 103-113 2004 0022-1503 https://www.documentation.ird.fr/hor/fdi:010078608 10.1093/jhered/esh023 0022-1503 [F B010078608] https://www.documentation.ird.fr/hor/fdi:010078608 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-07/010078608.pdf IRD - Base Horizon / Pleins textes 2020-07-16 2020-07-31 fdi:010078608 fre