Mendes A. M. auteur aut IRD Awono-Ambene P. H. auteur aut IRD Nsango S. E. auteur aut IRD Cohuet Anna auteur aut IRD Fontenille Didier auteur aut IRD Kafatos F. C. auteur aut IRD Christophides G. K. auteur aut IRD Morlais Isabelle auteur aut IRD Vlachou D. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Malaria remains a devastating disease despite efforts at control and prevention. Extensive studies using mostly rodent infection models reveal that successful Plasmodium parasite transmission by the African mosquito vector Anopheles gambiae depends on finely tuned vector-parasite interactions. Here we investigate the transcriptional response of A. gambiae to geographically related Plasmodium falciparum populations at various infection intensities and different infection stages. These responses are compared with those of mosquitoes infected with the rodent parasite Plasmodium berghei. We demonstrate that mosquito responses are largely dependent on the intensity of infection. A major transcriptional suppression of genes involved in the regulation of midgut homeostasis is detected in low-intensity P. falciparum infections, the most common type of infection in Africa. Importantly, genes transcriptionally induced during these infections tend to be phylogenetically unique to A. gambiae. These data suggest that coadaptation between vectors and parasites may act to minimize the impact of infection on mosquito fitness by selectively suppressing specific functional classes of genes. RNA interference (RNAi)-mediated gene silencing provides initial evidence for important roles of the mosquito G protein-coupled receptors (GPCRs) in controlling infection intensity-dependent antiparasitic responses. specialized 052 79 11 4708-4715 2011 0019-9567 https://www.documentation.ird.fr/hor/fdi:010078586 10.1128/iai.05647-11 0019-9567 https://www.documentation.ird.fr/hor/fdi:010078586 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-07/010078586.pdf IRD - Base Horizon / Pleins textes 2011-11-30 2020-07-31 fdi:010078586 fre