Ouji M. auteur aut IRD Bourgeade-Delmas Sandra auteur aut IRD Alvaro Fernández A. auteur aut IRD Augereau J.M. auteur aut IRD Valentin A. auteur aut IRD Hennert C. auteur aut IRD Gornitzka H. auteur aut IRD Benoit-Vical F. auteur aut IRD text journalArticle eng text/pdf born digital access The emergence of resistant parasites, Plasmodium and Leishmania, responsible of malaria and leishmaniasis diseases, to the currently available drugs, remains one of the major threats to public health. Therefore, there is an urgent need to develop new molecules. Several hybrid molecules combining triclosan and gold (I) complexes have been synthesized and evaluated, in vitro, for their activities on P. falciparum and L. infantum parasites. The obtained results showed a good activity of the compounds. However, the cytotoxicity assays suggest a structure modulation to improve the selectivity. The synthesized molecules were also tested in a context of Plasmodium falciparum artemisinin-resistance and the results showed no cross-resistance induced between one gold(I) complex and artemisinin. This highlights that these compounds appear as a strong basis for further pharmacomodulation work to propose molecules targeting resistant parasites. specialized 020 052 5 2 619-625 2020 2365-6549 https://www.documentation.ird.fr/hor/fdi:010078470 10.1002/slct.201904345 2365-6549 [F B010078470] https://www.documentation.ird.fr/hor/fdi:010078470 https://www.documentation.ird.fr/intranet/publi/depot/2020-03-30/010078470.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2020-03-27 2025-02-24 fdi:010078470 fre