@article{fdi:010078445,
  title = {{I}mpact of highly active antiretroviral therapy on chronic hepatitis {B} serological markers among {S}enegalese {HIV} co-infected children},
  author = {{B}a, {A}. and {N}diaye, {F}.{K}. and {D}jeng, {Y}.{J}. and {C}ames, {C}{\'e}cile and {D}iack, {A}. and {N}'diaye, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {C}oinfection with human immunodeficiency virus ({HIV}) and hepatitis {B} virus ({HBV}) causes complex interactions. {T}he aim of this study was to evaluate the seroprevalence and {HBV} evolution among {HIV} coinfected children receiving highly active antiretroviral therapy ({HAART}).
{M}ethods: {A} descriptive cross-sectional study was carried out among 252 {HIV} infected children enrolled in the {H}{\^o}pital d'enfants {A}lbert {R}oyer, {D}akar, {S}enegal, from {A}pril 2013 to {M}arch 2015. {C}linical characteristics, immuno-virological status, alanine aminotransferase ({ALT}) levels, and {HBV} serological marker were taken from the patients' medical records.
{R}esults: {O}verall, 7 children were {HB}s{A}g positive with a determinate prevalence rate of 2.8%. {M}edian age at {HIV} diagnosis was 3.5 years (1.3-14.4 years). {A}ccording to {W}orld {H}ealth {O}rganization ({WHO}) staging, 40.1% of children were stage 4 and 25.8% were stage 3. {O}f the 7 {HIV}/{HBV}-co-infected children, 6 (86%) received lamivudine alone at initiation of treatment, and only one child received tenofovir associated with emtricitabine. {O}verall median {HAART} duration treatment including  lamivudine alone or tenofovir+lamivudine (or emtricitabine) was 7.7 years (3.3-11.3). {O}nly the two children (29%) receiving lamivudine during follow-up had high {HBV} {DNA} load despite having good immuno-virological status. {S}uppression of {HBV} {DNA} replication was achieved in 5 (71.4%) of 7 children.
{C}onclusion and {G}lobal {H}ealth {I}mplication: {HIV}/{HBV} coinfection prevalence was low in our study. {HB}s{A}g and {HB}e{A}g loss were low while suppression of {HBV} {DNA} replication was still higher on tenofovir. {S}creening and monitoring {HBV} infection among all {HIV} infected children are required to direct treatment in order to improve children {HBV}/{HIV} coinfected outcome.},
  keywords = {{SENEGAL} ; {DAKAR}},
  booktitle = {},
  journal = {{T}he {I}nternational {J}ournal of {M}aternal and {C}hild {H}ealth and {AIDS}},
  volume = {8},
  numero = {2},
  pages = {131--137},
  ISSN = {2161-864{X}},
  year = {2019},
  URL = {https://www.documentation.ird.fr/hor/fdi:010078445},
}