Gazanion E. auteur aut IRD Vergnes Baptiste auteur aut IRD text bookSection eng text/pdf born digital access Diseases caused by protozoan parasites have a major impact on world health. These early branching eukaryotes cause significant morbidity and mortality in humans and livestock. During evolution, protozoan parasites have evolved toward complex life cycles in multiple host organisms with different nutritional resources. The conservation of functional metabolic pathways required for these successive environments is therefore a prerequisite for parasitic lifestyle. Nevertheless, parasitism drives genome evolution toward gene loss and metabolic dependencies (including strict auxotrophy), especially for obligatory intracellular parasites. In this chapter, we will compare and contrast how protozoan parasites have perfected this metabolic adaptation by focusing on specific auxotrophic pathways and scavenging strategies used by clinically relevant apicomplexan and trypanosomatid parasites to access host's nutritional resources. We will further see how these metabolic dependencies have in turn been exploited for therapeutic purposes against these human pathogens. specialized BIOLOGIE DU PARASITE CYCLE DE DEVELOPPEMENT METABOLISME BIOSYNTHESE GENETIQUE EVOLUTION RELATION HOTE PARASITE AUXOTROPHIE 052 020BIOCHI Silvestre R. ed. edt IRD Torrado E. ed. edt IRD 109 351-375 Cham Springer 2018 109 https://www.documentation.ird.fr/hor/fdi:010078394 10.1007/978-3-319-74932-7_9 978-3-319-74932-7 [F B010078394] https://www.documentation.ird.fr/hor/fdi:010078394 https://www.documentation.ird.fr/intranet/publi/depot/2020-06-12/010078394.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2020-06-19 2024-08-12 fdi:010078394 fre