%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Sow, D.
%A Ndiaye, M.
%A Sarr, L.
%A Kante, M. D.
%A Ly, F.
%A Diousse, P.
%A Faye, B. T.
%A Gaye, A. M.
%A Sokhna, Cheikh
%A Ranque, S.
%A Faye, B.
%T Mycetoma epidemiology, diagnosis management, and outcome in three hospital centres in Senegal from 2008 to 2018
%D 2020
%L fdi:010078134
%G ENG
%J PLoS One
%@ 1932-6203
%K SENEGAL
%M ISI:000536647300026
%N 4
%P art. e0231871 [13 ]
%R 10.1371/journal.pone.0231871
%U https://www.documentation.ird.fr/hor/fdi:010078134
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-06/010078134.pdf
%V 15
%W Horizon (IRD)
%X Mycetoma is a neglected tropical disease caused by various actinomycetes or fungi. The disease is characterized by the formation of tumor like-swellings and grains. Senegal is an endemic country where mycetoma cases are under-or misdiagnosed due to the lack of capacities and knowledge among health workers and the community; and where the management of eumycetoma, burdened by a high amputation rate, is currently inadequate. This study aimed to update data on the epidemiology of mycetoma cases diagnosed in three hospital centres in Senegal over a 10 years-period. A total of 193 patients, diagnosed from 2008 to 2018, were included in the study. The most frequent presentation was eumycetoma (47.2%); followed by actinomycetoma (36.8%); it remained undetermined in 16.1% of the patients. The mean age was 38.3 years (68.4% of the patients were between 15 and 45 years-old); the male: female ratio was a 2.94; and most were farmers. One hundred fifty-six (80.8%) patients had used phytotherapy before attending the hospital. Mycetoma was mainly located to the lower limbs (91.2%). Grains were observed in 85% of the patients; including white (25.6%) and yellow (4.3%) grains. The etiological diagnosis was complex, resulting in negative direct microscopy, culture and/or histopathology findings, which explains that 16.1% remained uncharacterized. In most of cases, actinomycetoma were treated with a combination of cotrimoxazole, amoxicillin/clavulanic acid, and streptomycin; whereas eumycetoma cases were treated with terbinafine. The surgery was done in 100 (51.8%) of the patients including 9 in actinomycetoma, 78 in eumycetoma and 13 in undetermined form. The high number of uncharacterized mycetoma in this study, the delay in attending a qualified health-care facility, and the lack of available adequate antifungal drug, point out the need to strengthen mycetoma management capacities in Senegal.
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