Publications des scientifiques de l'IRD

Sow D., Ndiaye M., Sarr L., Kante M. D., Ly F., Diousse P., Faye B. T., Gaye A. M., Sokhna Cheikh, Ranque S., Faye B. (2020). Mycetoma epidemiology, diagnosis management, and outcome in three hospital centres in Senegal from 2008 to 2018. PLoS One, 15 (4), p. art. e0231871 [13 p.]. ISSN 1932-6203.

Titre du document
Mycetoma epidemiology, diagnosis management, and outcome in three hospital centres in Senegal from 2008 to 2018
Année de publication
2020
Type de document
Article référencé dans le Web of Science WOS:000536647300026
Auteurs
Sow D., Ndiaye M., Sarr L., Kante M. D., Ly F., Diousse P., Faye B. T., Gaye A. M., Sokhna Cheikh, Ranque S., Faye B.
Source
PLoS One, 2020, 15 (4), p. art. e0231871 [13 p.] ISSN 1932-6203
Mycetoma is a neglected tropical disease caused by various actinomycetes or fungi. The disease is characterized by the formation of tumor like-swellings and grains. Senegal is an endemic country where mycetoma cases are under-or misdiagnosed due to the lack of capacities and knowledge among health workers and the community; and where the management of eumycetoma, burdened by a high amputation rate, is currently inadequate. This study aimed to update data on the epidemiology of mycetoma cases diagnosed in three hospital centres in Senegal over a 10 years-period. A total of 193 patients, diagnosed from 2008 to 2018, were included in the study. The most frequent presentation was eumycetoma (47.2%); followed by actinomycetoma (36.8%); it remained undetermined in 16.1% of the patients. The mean age was 38.3 years (68.4% of the patients were between 15 and 45 years-old); the male: female ratio was a 2.94; and most were farmers. One hundred fifty-six (80.8%) patients had used phytotherapy before attending the hospital. Mycetoma was mainly located to the lower limbs (91.2%). Grains were observed in 85% of the patients; including white (25.6%) and yellow (4.3%) grains. The etiological diagnosis was complex, resulting in negative direct microscopy, culture and/or histopathology findings, which explains that 16.1% remained uncharacterized. In most of cases, actinomycetoma were treated with a combination of cotrimoxazole, amoxicillin/clavulanic acid, and streptomycin; whereas eumycetoma cases were treated with terbinafine. The surgery was done in 100 (51.8%) of the patients including 9 in actinomycetoma, 78 in eumycetoma and 13 in undetermined form. The high number of uncharacterized mycetoma in this study, the delay in attending a qualified health-care facility, and the lack of available adequate antifungal drug, point out the need to strengthen mycetoma management capacities in Senegal.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
SENEGAL
Localisation
Fonds IRD [F B010078134]
Identifiant IRD
fdi:010078134
Contact