%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Khamduang, W.
%A Kaewbundit, A.
%A Duangmano, A.
%A Hongjaisee, S.
%A Klinbuayaem, V.
%A Halue, G.
%A Chutanunta, A.
%A Sirirungsi, W.
%A Jourdain, Gonzague
%A Ngo-Giang-Huong, Nicole
%T HIV RNA measurement in dried blood spots of HIV-infected patients in Thailand using Abbott m2000 system
%D 2020
%L fdi:010078131
%G ENG
%J PLoS One
%@ 1932-6203
%K THAILANDE
%M ISI:000534599100081
%N 1
%P art. e0227929 [8 ]
%R 10.1371/journal.pone.0227929
%U https://www.documentation.ird.fr/hor/fdi:010078131
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-06/010078131.pdf
%V 15
%W Horizon (IRD)
%X World Health Organization recommends using dried blood spots (DBS) for HIV RNA viral load (VL) measurement whenever plasma processing is not convenient or feasible. DBS collected from 80 treatment-naive HIV-infected patients presenting in three hospitals of two different regions of Thailand were shipped to a central laboratory along with corresponding plasma specimens. Viral load was measured in both DBS and plasma using the Abbott m2000 system. HIV RNA levels were strongly correlated (r = 0.94) with a mean of differences of 0.23 log(10) copies/mL. Using the 1,000 copies/mL cut-off, the sensitivity of DBS was 97% (95%CI, 91-100%) and specificity was 75% (95%CI, 19-99%). DBS are useful to scale-up HIV RNA VL testing in settings with limited access to VL testing.
%$ 052 ; 020