@article{fdi:010078125,
  title = {{E}ffects of an injectable long-acting formulation of ivermectin on {O}nchocerca ochengi in zebu cattle},
  author = {{B}oussinesq, {M}ichel and {E}nyong, {P}. and {C}hounna-{N}dongmo, {P}. and {N}jouendou, {A}. {J}. and {P}ion, {S}{\'e}bastien and {R}ech, {A}. and {R}oberge, {C}. and {G}audriault, {G}. and {W}anji, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he availability of a safe macrofilaricidal drug would help to accelerate onchocerciasis elimination. {A} trial was conducted in {C}ameroon to evaluate the effects of a subcutaneous injectable long-acting formulation of ivermectin ({LAFI}) on the microfilariae (mf) and adult stages of {O}nchocerca ochengi. {T}en zebu cattle naturally infected with the parasite were injected subcutaneously with either 500 mg (group {A}, {N} = 4), or 1000 mg long-acting ivermectin (group {B}, {N} = 4) or the vehicle (group {C}, {N} = 2). {S}kin samples were collected from each animal before, and 6, 12, and 24 months after treatment to measure microfilarial densities ({MFD}s). {N}odules excised before, and 6 and 12 months after treatment were examined histologically to assess the adult worms' viability and reproductive status. {B}lood samples were collected at pre-determined time-points to obtain pharmacokinetic data. {B}efore treatment, the average {O}. ochengi {MFD}s were similar in the three groups. {S}ix months after treatment, all animals in groups {A} and {B} were free of skin mf, whereas those in group {C} still showed high {MFD}s (mean = 324.5 mf/g). {O}nly one ivermectin-treated animal (belonging to group {A}) had skin mf 12 months after treatment (0.9 mf/g). {A}t 24 months, another animal in group {A} showed skin mf (10.0 mf/g). {T}he histologic examination of nodules at 6 and 12 months showed that {LAFI} was not macrofilaricidal but had a strong effect on embryogenesis. {T}he new {LAFI} regimen might be an additional tool to accelerate the elimination of human onchocerciasis in specific settings.},
  keywords = {{O}nchocerciasis ; {O}nchocerca ochengi ; {I}vermectin ; {L}ong-acting formulation ; {M}icrofilaricidal effect ; {M}acrofilaricidal effect ; {CAMEROUN} ; {ADAMAOUA}},
  booktitle = {},
  journal = {{P}arasite},
  volume = {27},
  numero = {},
  pages = {art. 36 [10 ]},
  ISSN = {1252-607{X}},
  year = {2020},
  DOI = {10.1051/parasite/2020036},
  URL = {https://www.documentation.ird.fr/hor/fdi:010078125},
}