@article{fdi:010078088,
  title = {{I}dentification and characterization of compounds from {C}hrysosporium multifidum, a fungus with moderate antimicrobial activity isolated from {H}ermetia illucens gut microbiota},
  author = {{C}orrea, {Y}. and {C}abanillas, {B}. and {J}ullian, {V}al{\'e}rie and {A}lvarez, {D}. and {C}astillo, {D}. and {D}ufloer, {C}edric and {B}ustamante, {B}. and {R}oncal, {E}. and {N}eyra, {E}. and {S}heen, {P}. and {S}auvain, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he gut microbiota of insects is composed of a wide range of microorganisms which produce bioactive compounds that protect their host from pathogenic attack. {I}n the present study, we isolate and identify the fungus {C}hrysosporium multifidum from the gut of {H}ermetia illucens larvae. {E}xtract from {C}. multifidum culture broth supernatant showed moderate activity against a strain of methicillin-resistant {S}taphylococcus aureus ({MRSA}). {B}ioguided isolation of the extract resulted in the characterization of six a- pyrone derivatives (1-6) and one diketopiperazine (7). {O}f these compounds, 5,6-dihydro-4-methoxy-6-(1-oxopentyl)-2{H}-pyran-2-one (4) showed the greatest activity ({IC}50 = 11.4 +/- 0.7 mu g/m{L} and {MIC} = 62.5 mu g/m{L}) against {MRSA}.},
  keywords = {},
  booktitle = {},
  journal = {{PL}o{S} {O}ne},
  volume = {14},
  numero = {12},
  pages = {e0218837 [10 ]},
  ISSN = {1932-6203},
  year = {2019},
  DOI = {10.1371/journal.pone.0218837},
  URL = {https://www.documentation.ird.fr/hor/fdi:010078088},
}