@article{fdi:010078061,
  title = {{A}ssessment of glucose-6-phosphate dehydrogenase activity using {C}are{S}tart {G}6{PD} rapid diagnostic test and associated genetic variants in {P}lasmodium vivax malaria endemic setting in {M}auritania},
  author = {{D}jigo, {O}. {K}. {M}. and {B}ollahi, {M}. {A}. and {E}bou, {M}. {H}. and {O}uld {A}hmedou {S}alem, {M}. {S}. and {T}ahar, {R}achida and {B}ogreau, {H}. and {B}asco, {L}eonardo and {O}uld {M}ohamed {S}alem {B}oukhary, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {P}rimaquine is recommended by the {W}orld {H}ealth {O}rganization ({WHO}) for radical treatment of {P}lasmodium vivax malaria. {T}his drug is known to provoke acute hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase ({G}6{PD}) deficiency. {D}ue to lack of data on {G}6{PD} deficiency, the use of primaquine has been limited in {A}frica. {I}n the present study, {G}6{PD} deficiency was investigated in blood donors of various ethnic groups living in {N}ouakchott, a {P}. vivaxendemic area in {M}auritania. {M}ethodology/{P}rincipal findings {V}enous blood samples from 443 healthy blood donors recruited at the {N}ational {T}ransfusion {C}enter in {N}ouakchott were screened for {G}6{PD} activity using the {C}are{S}tart {G}6{PD} deficiency rapid diagnostic test. {G}6{PD} allelic variants were investigated using {D}ia{P}lex{C} {G}6{PD} genotyping kit that detects {A}frican ({A}-) and {M}editerranean ({B}-) variants. {O}verall, 50 of 443 (11.3%) individuals (49 [11.8%] men and 1 [3.7%] woman) were phenotypically deficient. {A}mongst men, {B}lack {A}fricans had the highest prevalence of {G}6{PD} deficiency (15 of 100 [15%]) and {W}hite {M}oors the lowest (10 of 168, [5.9%]). {T}he most commonly observed {G}6{PD} allelic variants among 44 tested {G}6{PD}-deficient men were the {A}frican variant {K} (202{A}/376{G}) in 14 (31.8%), the {M}editerranean variant {B}- (563{T}) in 13 (29.5%), and the {B}etica-{S}elma {K} (376{G}/968{C}) allelic variant in 6 (13.6%). {T}he {S}antamaria {K} variant (376{G}/ 542{T}) and {A} variant (376{G}) were observed in only one and two individuals, respectively. {N}one of the expected variants was observed in 8 (18.2%) of the tested phenotypically {G}6{PD}-deficient men. {C}onclusion {T}his is the first published data on {G}6{PD} deficiency in {M}auritanians. {T}he prevalence of phenotypic {G}6{PD} deficiency was relatively high (11.3%). {I}t was mostly associated with either {A}frican or {M}editerranean variants, in agreement with diverse {A}rab and {B}lack {A}frican origins of the {M}auritanian population.},
  keywords = {{MAURITANIE}},
  booktitle = {},
  journal = {{PL}o{S} {O}ne},
  volume = {14},
  numero = {9},
  pages = {art. e0220977 [11p.]},
  ISSN = {1932-6203},
  year = {2019},
  DOI = {10.1371/journal.pone.0220977},
  URL = {https://www.documentation.ird.fr/hor/fdi:010078061},
}