@article{fdi:010077979,
  title = {{S}chistosoma haematobium infection modulates {P}lasmodium falciparum parasite density and antimalarial antibody responses},
  author = {{T}okplonou, {L}. and {N}ouatin, {O}. and {S}onon, {P}. and {M}'po, {G}. and {G}litho, {S}. and {A}gniwo, {P}. and {G}onzalez-{O}rtiz, {D}. and {T}chegninougbo, {T}. and {A}yitchedji, {A}. and {F}avier, {B}. and {D}onadi, {E}. {A}. and {M}ilet, {J}acqueline and {L}uty, {A}drian and {M}assougbodji, {A}. and {G}arcia, {A}ndr{\'e} and {I}bikounle, {M}. and {C}ourtin, {D}avid},
  editor = {},
  language = {{ENG}},
  abstract = {{A}ims {S}chistosomiasis and malaria are endemic in sub-{S}aharan {A}frica where {S}chistosoma haematobium ({S}h) and {P}lasmodium falciparum ({P}f) coinfections are thus frequent. {W}e explored the effect of {S}h infection on antibody responses directed to {P}f merozoite antigens and on malaria susceptibility in {B}eninese children. {M}ethods and results {A} total of 268 children were followed during a malaria transmission season. {D}etection of {P}f infection was performed by microscopy and rapid diagnostic tests. {S}h infection was determined in urine by microscopy. {A}ntimalarial antibody, cytokine and {HLA}-{G} concentrations were quantified by {ELISA}. {T}he expression of {HLA}-{G} receptors by immune cells was assessed by flow cytometry. {C}hildren infected by {S}h had higher concentrations of {I}g{G}1 directed to {MSP}3 and {GLURP}({R}0), {I}g{G}2 directed to {GLURP}({R}0) and {I}g{G}3 directed to {MSP}3, {GLURP}({R}0) and {GLURP}({R}2) and have lower {P}f densities than those uninfected by {S}h. {N}o difference in cytokine and {HLA}-{G} concentrations was observed between {S}h egg carriers and non-carriers. {C}onclusion {S}chistosoma haematobium modulates host immune responses directed to {P}f antigens. {T}he absence of immune downregulation usually observed during helminth infections is surprising in our study. {W}e hypothesize that the stage of {S}h development could partly explain the immune pathways leading to increased antibody levels that favour better control of {P}f parasitemia.},
  keywords = {coinfection ; {HLA}-{G} ; {LILRB}1 and {LILRB}2 ; malaria ; {P}. falciparum ; {S}. haematobium ; {BENIN}},
  booktitle = {},
  journal = {{P}arasite {I}mmunology},
  volume = {42},
  numero = {4},
  pages = {e12702 [13 ]},
  ISSN = {0141-9838},
  year = {2020},
  DOI = {10.1111/pim.12702},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077979},
}