Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Microorganisms art. 138 [15 ] [+ Correction, 2020, vol.8, no 9, art. 1384] bats Gram-negative bacteria ESBL multiresistance reservoir GABON MAKOKOU 2020 fdi:010077967 ENG Microorganisms ISI:000514650700052 1 10.3390/microorganisms8010138 https://www.documentation.ird.fr/hor/fdi:010077967 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-04/010077967.pdf 8 Horizon (IRD) In Gabon, terrestrial mammals of protected areas have been identified as a possible source of antibiotic-resistant bacteria. Some studies on antibiotic resistance in bats have already been carried out. The main goal of our study was to detect extended-spectrum beta-lactamases (ESBLs) that are produced by enterobacteria from bats in the Makokou region in Gabon. Sixty-eight fecal samples were obtained from 68 bats caught in the forests located 1 km from the little town of Makokou. After culture and isolation, 66 Gram-negative bacterial colonies were obtained. The double-disk diffusion test confirmed the presence of ESBLs in six (20.69%) Escherichia coli isolates, four (13.79%) Klebsiella pneumoniae isolates, and one (3.45%) Enterobacter cloacae isolate. The analysis based on the nucleotide sequences of the ESBL resistance genes showed that all cefotaximase-Munichs (CTX-Ms) were CTX-M-15 and that all sulfhydryl variables (SHVs) were SHV-11: 41.67% CTX-M-15-producing E. coli, 16.67% CTX-M-15+SHV-11-producing E. coli, 8.33% CTX-M-15-producing K. pneumoniae, 25% CTX-M-15+SHV-11-producing K. pneumoniae, and 8.33% CTX-M-15-produced E. cloacae. This study shows for the first time the presence of multiresistant ESBL-producing enterobacteria in fruit bats in Makokou. 080 ; 084 UR224 Algérie / Gabon