Carboué Q. auteur aut IRD Maresca M. auteur aut IRD Herbette G. auteur aut IRD Roussos Sevastianos auteur aut IRD Hamrouni R. auteur aut IRD Bombarda I. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Seven naphtho-gamma-pyrones (N gamma Ps), including asperpyrone E, aurasperone A, dianhydroaurasperone C, fonsecin, fonsecinone A, fonsecin B, and ustilaginoidin A, were isolated from Aspergillus tubingensis G131, a non-toxigenic strain. The radical scavenging activity of these N gamma Ps was evaluated using ABTS assay. The Trolox equivalent antioxidant capacity on the seven isolated N gamma Ps ranged from 2.4 to 14.6 mu mol L-1. The toxicity and ability of the N gamma Ps to prevent H2O2-mediated cell death were evaluated using normal/not cancerous cells (CHO cells). This cell-based assay showed that N gamma Ps: (1) Are not toxic or weakly toxic towards cells and (2) are able to protect cells from oxidant injuries with an IC50 on H2O2-mediated cell death ranging from 2.25 to 1800 mu mol mL(-1). Our data show that A. tubingensis G131 strain is able to produce various N gamma Ps possessing strong antioxidant activities and low toxicities, making this strain a good candidate for antioxidant applications in food and cosmetic industries. specialized naphtho-gamma-pyrones radical scavenging activity hydrogen peroxide mediated cell death assay solid state fermentation Aspergillus tubingensis 084 020 10 1 art. 29 [15 ] 2020 https://www.documentation.ird.fr/hor/fdi:010077960 10.3390/biom10010029 [F B010077960] https://www.documentation.ird.fr/hor/fdi:010077960 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-04/010077960.pdf IRD - Base Horizon / Pleins textes 2020-05-18 2025-02-24 fdi:010077960 fre