%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Abbate, J. L.
%A Becquart, Pierre
%A Leroy, Eric
%A Ezenwa, V. O.
%A Roche, Benjamin
%T Exposure to Ebola virus and risk for infection with malaria parasites, rural Gabon
%D 2020
%L fdi:010077937
%G ENG
%J Emerging Infectious Diseases
%@ 1080-6040
%K GABON
%M ISI:000510436500006
%N 2
%P 229-237
%R 10.3201/eid2602.181120
%U https://www.documentation.ird.fr/hor/fdi:010077937
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-04/010077937.pdf
%V 26
%W Horizon (IRD)
%X An association between malaria and risk for death among patients with Ebola virus disease has suggested within-host interactions between Plasmodium falciparum parasites and Ebola virus. To determine whether such an interaction might also influence the probability of acquiring either infection, we used a large snapshot surveillance study from rural Gabon to test if past exposure to Ebola virus is associated with current infection with Plasmodium spp. during nonepidemic conditions. We found a strong positive association, on population and individual levels, between seropositivity for antibodies against Ebola virus and the presence of Plasmodium parasites in the blood. According to a multiple regression model accounting for other key variables, antibodies against Ebola virus emerged as the strongest individual-level risk factor for acquiring malaria. Our results suggest that within-host interactions between malaria parasites and Ebola virus may underlie epidemiologic associations.
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