@article{fdi:010077928,
  title = {{V}irus-based pharmaceutical production in plants : an opportunity to reduce health problems in {A}frica},
  author = {{B}amogo, {P}. {K}. {A}. and {B}rugidou, {C}hristophe and {S}{\'e}r{\'e}m{\'e}, {D}. and {T}iendr{\'e}b{\'e}ogo, {F}. and {D}jigma, {F}. {W}. and {S}impore, {J}. and {L}acombe, {S}{\'e}verine},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {D}eveloping {A}frican countries face health problems that they struggle to solve. {T}he major causes of this situation are high therapeutic and logistical costs. {P}lant-made therapeutics are easy to produce due to the lack of the safety considerations associated with traditional fermenter-based expression platforms, such as mammalian cells. {P}lant biosystems are easy to scale up and inexpensive, and they do not require refrigeration or a sophisticated medical infrastructure. {T}hese advantages provide an opportunity for plant-made pharmaceuticals to counteract diseases for which medicines were previously inaccessible to people in countries with few resources. {M}ain body {T}he techniques needed for plant-based therapeutic production are currently available. {V}iral expression vectors based on plant viruses have greatly enhanced plant-made therapeutic production and have been exploited to produce a variety of proteins of industrial, pharmaceutical and agribusiness interest. {S}ome neglected tropical diseases occurring exclusively in the developing world have found solutions through plant bioreactor technology. {P}lant viral expression vectors have been reported in the production of therapeutics against these diseases occurring exclusively in the third world, and some virus-derived antigens produced in plants exhibit appropriate antigenicity and immunogenicity. {H}owever, all advances in the use of plants as bioreactors have been made by companies in {E}urope and {A}merica. {T}he developing world is still far from acquiring this technology, although plant viral expression vectors may provide crucial help to overcome neglected diseases. {C}onclusion {T}oday, interest in these tools is rising, and viral amplicons made in and for {A}frica are in progress. {T}his review describes the biotechnological advances in the field of plant bioreactors, highlights factors restricting access to this technology by those who need it most and proposes a solution to overcome these limitations.},
  keywords = {{P}lant viral expression vectors ; {P}lant-made therapeutics ; {R}ecombinant proteins ; {N}eglected diseases ; {D}eveloping {A}frican countries ; {AFRIQUE}},
  booktitle = {},
  journal = {{V}irology {J}ournal},
  volume = {16},
  numero = {1},
  pages = {art. 167 [16 p.]},
  year = {2019},
  DOI = {10.1186/s12985-019-1263-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077928},
}