@article{fdi:010077901,
  title = {{N}ew {WHO} guidelines for treatment of gambiense human {A}frican trypanosomiasis including fexinidazole : substantial changes for clinical practice},
  author = {{L}indner, {A}. {K}. and {L}ejon, {V}eerle and {C}happuis, {F}. and {S}eixas, {J}. and {K}azumba, {L}. and {B}arrett, {M}. {P}. and {M}wamba, {E}. and {E}rphas, {O}. and {A}kl, {E}. {A}. and {V}illanueva, {G}. and {B}ergman, {H}. and {S}imarro, {P}. and {E}beja, {A}. {K}. and {P}riotto, {G}. and {F}ranco, {J}. {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{H}uman {A}frican trypanosomiasis caused by {T}rypanosoma brucei gambiense is a parasitic infection that usually progresses to coma and death unless treated. {WHO} has updated its guidelines for the treatment of this infection on the basis of independent literature reviews and using the {G}rading of {R}ecommendations {A}ssessment, {D}evelopment and {E}valuation methodology. {T}he first-line treatment options, pentamidine and nifurtimox-eflornithine combination therapy, have been expanded to include fexinidazole, an oral monotherapy given a positive opinion from the {E}uropean {M}edicines {A}gency. {F}exinidazole is recommended for individuals who are aged 6 years and older with a bodyweight of 20 kg or more, who have first-stage or second-stage gambiense human {A}frican trypanosomiasis and a cerebrospinal fluid leucocyte count less than 100 per mu {L}. {N}ifurtimox-eflornithine combination therapy remains recommended for patients with 100 leucocytes per mu {L} or more. {W}ithout clinical suspicion of severe second-stage disease, lumbar puncture can be avoided and fexinidazole can be given. {F}exinidazole should only be administered under supervision of trained health staff. {B}ecause these recommendations are expected to change clinical practice considerably, health professionals should consult the detailed {WHO} guidelines. {T}hese guidelines will be updated as evidence accrues.},
  keywords = {{AFRIQUE}},
  booktitle = {},
  journal = {{L}ancet {I}nfectious {D}iseases},
  volume = {20},
  numero = {2},
  pages = {{E}38--{E}46},
  ISSN = {1473-3099},
  year = {2020},
  DOI = {10.1016/s1473-3099(19)30612-7},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077901},
}