@article{fdi:010077874,
  title = {{A}ntileishmanial compounds isolated from {P}sidium guajava {L}. using a metabolomic approach},
  author = {{P}hakeovilay, {C}. and {B}ourgeade-{D}elmas, {S}andra and {P}erio, {P}ierre and {V}alentin, {A}. and {C}hassagne, {F}. and {D}eharo, {E}ric and {R}eybier, {K}. and {M}arti, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}ith an estimated annual incidence of one million cases, leishmaniasis is one of the top five vector-borne diseases. {C}urrently available medical treatments involve side effects, including toxicity, non-specific targeting, and resistance development. {T}hus, new antileishmanial chemical entities are of the utmost interest to fight against this disease. {T}he aim of this study was to obtain potential antileishmanial natural products from {P}sidium guajava leaves using a metabolomic workflow. {S}everal crude extracts from {P}. guajava leaves harvested from different locations in the {L}ao {P}eople's {D}emocratic {R}epublic ({L}ao {PDR}) were profiled by liquid chromatography coupled to high-resolution mass spectrometry, and subsequently evaluated for their antileishmanial activities. {T}he putative active compounds were highlighted by multivariate correlation analysis between the antileishmanial response and chromatographic profiles of {P}. guajava mixtures. {T}he results showed that the pooled apolar fractions from {P}. guajava were the most active ({IC}50 = 1.96 +/- 0.47 mu g/m{L}). {M}ultivariate data analysis of the apolar fractions highlighted a family of triterpenoid compounds, including jacoumaric acid ({IC}50 = 1.318 +/- 0.59 mu g/m{L}) and corosolic acid ({IC}50 = 1.01 +/- 0.06 mu g/m{L}). {O}ur approach allowed the identification of antileishmanial compounds from the crude extracts in only a small number of steps and can be easily adapted for use in the discovery workflows of several other natural products.},
  keywords = {metabolomic ; antileishmanial activity ; metabolomics ; {P}sidium guajava ; jacoumaric acid ; corosolic acid},
  booktitle = {},
  journal = {{M}olecules},
  volume = {24},
  numero = {24},
  pages = {art. 4536 [13p.]},
  year = {2019},
  DOI = {10.3390/molecules24244536},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077874},
}