Bartlett A. W. auteur aut IRD Lumbiganon P. auteur aut IRD Mohamed T. A. J. auteur aut IRD Lapphra K. auteur aut IRD Muktiarti D. auteur aut IRD Du Q. T. auteur aut IRD Hansudewechakul R. auteur aut IRD Ly P. S. auteur aut IRD Truong K. H. auteur aut IRD Nguyen L. V. auteur aut IRD Puthanakit T. auteur aut IRD Sudjaritruk T. auteur aut IRD Chokephaibulkit K. auteur aut IRD Do V. C. auteur aut IRD Kumarasamy N. auteur aut IRD Yusoff N. K. N. auteur aut IRD Kurniati N. auteur aut IRD Fong M. S. auteur aut IRD Wati D. K. auteur aut IRD Nallusamy R. auteur aut IRD Sohn A. H. auteur aut IRD Kariminia A. auteur aut IRD Khol V. auteur aut IRD Tucker J. auteur aut IRD Ezhilarasi C. auteur aut IRD Kinikar A. auteur aut IRD Mave V. auteur aut IRD Nimkar S. auteur aut IRD Vedaswari D. auteur aut IRD Ramajaya I. B. auteur aut IRD Fong S. M. auteur aut IRD Lim M. auteur aut IRD Daut F. auteur aut IRD Mohamad P. auteur aut IRD Mohamed T. J. auteur aut IRD Drawis M. R. auteur aut IRD Chan K. C. auteur aut IRD Sirisanthana V. auteur aut IRD Aurpibul L. auteur aut IRD Ounchanum P. auteur aut IRD Denjanta S. auteur aut IRD Kongphonoi A. auteur aut IRD Kosalaraksa P. auteur aut IRD Tharnprisan P. auteur aut IRD Udomphanit T. auteur aut IRD Jourdain Gonzague auteur aut IRD Anugulruengkit S. auteur aut IRD Jantarabenjakul W. auteur aut IRD Nadsasarn R. auteur aut IRD Phongsamart W. auteur aut IRD Sricharoenchai S. auteur aut IRD Nguyen C. H. auteur aut IRD Ha T. M. auteur aut IRD Khu D. T. K. auteur aut IRD Pham A. N. auteur aut IRD Nguyen L. T. auteur aut IRD Le O. N. auteur aut IRD Ross J. L. auteur aut IRD Suwanlerk T. auteur aut IRD Law M. G. auteur aut IRD TREAT Asia Pediatric HIV Observational Database of IeDEA Asia-Pacific auteur aut IRD text journalArticle eng text/pdf born digital access Background: Perinatally HIV-infected adolescents (PHIVA) are an expanding population vulnerable to loss to follow-up (LTFU). Understanding the epidemiology and factors for LTFU is complicated by varying LTFU definitions. Setting: Asian regional cohort incorporating 16 pediatric HIV services across 6 countries. Methods: Data from PHIVA (aged 10-19 years) who received combination antiretroviral therapy 2007-2016 were used to analyze LTFU through (1) an International epidemiology Databases to Evaluate AIDS (IeDEA) method that determined LTFU as >90 days late for an estimated next scheduled appointment without returning to care and (2) the absence of patient-level data for >365 days before the last data transfer from clinic sites. Descriptive analyses and competing-risk survival and regression analyses were used to evaluate LTFU epidemiology and associated factors when analyzed using each method. Results: Of 3509 included PHIVA, 275 (7.8%) met IeDEA and 149 (4.3%) met 365-day absence LTFU criteria. Cumulative incidence of LTFU was 19.9% and 11.8% using IeDEA and 365-day absence criteria, respectively. Risk factors for LTFU across both criteria included the following: age at combination antiretroviral therapy initiation <5 years compared with age >= 5 years, rural clinic settings compared with urban clinic settings, and high viral loads compared with undetectable viral loads. Age 10-14 years compared with age 15-19 years was another risk factor identified using 365-day absence criteria but not IeDEA LTFU criteria. Conclusions: Between 12% and 20% of PHIVA were determined LTFU with treatment fatigue and rural treatment settings consistent risk factors. Better tracking of adolescents is required to provide a definitive understanding of LTFU and optimize evidence-based models of care. specialized HIV adolescent loss to follow-up CAMBODGE INDE INDONESIE MALAISIE THAILANDE VIET NAM 052 050 82 5 431-438 2019 1525-4135 https://www.documentation.ird.fr/hor/fdi:010077837 10.1097/qai.0000000000002184 1525-4135 [F B010077837] https://www.documentation.ird.fr/hor/fdi:010077837 https://www.documentation.ird.fr/intranet/publi/2020/02/010077837.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2020-03-11 2020-03-12 fdi:010077837 fre