%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Bartlett, A. W.
%A Lumbiganon, P.
%A Mohamed, T. A. J.
%A Lapphra, K.
%A Muktiarti, D.
%A Du, Q. T.
%A Hansudewechakul, R.
%A Ly, P. S.
%A Truong, K. H.
%A Nguyen, L. V.
%A Puthanakit, T.
%A Sudjaritruk, T.
%A Chokephaibulkit, K.
%A Do, V. C.
%A Kumarasamy, N.
%A Yusoff, N. K. N.
%A Kurniati, N.
%A Fong, M. S.
%A Wati, D. K.
%A Nallusamy, R.
%A Sohn, A. H.
%A Kariminia, A.
%A Khol, V.
%A Tucker, J.
%A Ezhilarasi, C.
%A Kinikar, A.
%A Mave, V.
%A Nimkar, S.
%A Vedaswari, D.
%A Ramajaya, I. B.
%A Fong, S. M.
%A Lim, M.
%A Daut, F.
%A Mohamad, P.
%A Mohamed, T. J.
%A Drawis, M. R.
%A Chan, K. C.
%A Sirisanthana, V.
%A Aurpibul, L.
%A Ounchanum, P.
%A Denjanta, S.
%A Kongphonoi, A.
%A Kosalaraksa, P.
%A Tharnprisan, P.
%A Udomphanit, T.
%A Jourdain, Gonzague
%A Anugulruengkit, S.
%A Jantarabenjakul, W.
%A Nadsasarn, R.
%A Phongsamart, W.
%A Sricharoenchai, S.
%A Nguyen, C. H.
%A Ha, T. M.
%A Khu, D. T. K.
%A Pham, A. N.
%A Nguyen, L. T.
%A Le, O. N.
%A Ross, J. L.
%A Suwanlerk, T.
%A Law, M. G.
%A TREAT Asia Pediatric HIV Observational Database of IeDEA Asia-Pacific
%T Dual analysis of loss to follow-up for perinatally HIV-infected adolescents receiving combination antiretroviral therapy in Asia
%D 2019
%L fdi:010077837
%G ENG
%J JAIDS
%@ 1525-4135
%K HIV ; adolescent ; loss to follow-up
%K CAMBODGE ; INDE ; INDONESIE ; MALAISIE ; THAILANDE ; VIET NAM
%M ISI:000509686000004
%N 5
%P 431-438
%R 10.1097/qai.0000000000002184
%U https://www.documentation.ird.fr/hor/fdi:010077837
%> https://www.documentation.ird.fr/intranet/publi/2020/02/010077837.pdf
%V 82
%W Horizon (IRD)
%X Background: Perinatally HIV-infected adolescents (PHIVA) are an expanding population vulnerable to loss to follow-up (LTFU). Understanding the epidemiology and factors for LTFU is complicated by varying LTFU definitions. Setting: Asian regional cohort incorporating 16 pediatric HIV services across 6 countries. Methods: Data from PHIVA (aged 10-19 years) who received combination antiretroviral therapy 2007-2016 were used to analyze LTFU through (1) an International epidemiology Databases to Evaluate AIDS (IeDEA) method that determined LTFU as >90 days late for an estimated next scheduled appointment without returning to care and (2) the absence of patient-level data for >365 days before the last data transfer from clinic sites. Descriptive analyses and competing-risk survival and regression analyses were used to evaluate LTFU epidemiology and associated factors when analyzed using each method. Results: Of 3509 included PHIVA, 275 (7.8%) met IeDEA and 149 (4.3%) met 365-day absence LTFU criteria. Cumulative incidence of LTFU was 19.9% and 11.8% using IeDEA and 365-day absence criteria, respectively. Risk factors for LTFU across both criteria included the following: age at combination antiretroviral therapy initiation <5 years compared with age >= 5 years, rural clinic settings compared with urban clinic settings, and high viral loads compared with undetectable viral loads. Age 10-14 years compared with age 15-19 years was another risk factor identified using 365-day absence criteria but not IeDEA LTFU criteria. Conclusions: Between 12% and 20% of PHIVA were determined LTFU with treatment fatigue and rural treatment settings consistent risk factors. Better tracking of adolescents is required to provide a definitive understanding of LTFU and optimize evidence-based models of care.
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