@article{fdi:010077828,
  title = {{E}levated serum ceramides are linked with obesity-associated gut dysbiosis and impaired glucose metabolism},
  author = {{K}ayser, {B}. {D}. and {P}rifti, {E}. and {L}homme, {M}. and {B}elda, {E}. and {D}ao, {M}. {C}. and {A}ron-{W}isnewsky, {J}. and {K}ontush, {A}. and {Z}ucker, {J}ean-{D}aniel and {R}izkalla, {S}. {W}. and {D}ugail, {I}. and {C}lement, {K}. and {K}ennedy, {S}. {P}. and {P}ons, {N}. and {L}e {C}hatelier, {E}. and {A}lmeida, {M}. and {Q}uinquis, {B}. and {G}alleron, {N}. and {B}atto, {J}. {M}. and {R}enault, {P}. and {E}hrlich, {S}. {D}. and {B}lottiere, {H}. and {L}eclerc, {M}. and de {W}outers, {T}. and {L}epage, {P}. and {D}ore, {J}. and {MICRO}-{O}bes {C}onsortium},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction {L}ow gut microbiome richness is associated with dyslipidemia and insulin resistance, and ceramides and other sphingolipids are implicated in the development of diabetes. {O}bjectives {D}etermine whether circulating sphingolipids, particularly ceramides, are associated with alterations in the gut microbiome among obese patients with increased diabetes risk. {M}ethods {T}his was a cross-sectional and longitudinal retrospective analysis of a dietary/weight loss intervention. {F}asted serum was collected from 49 participants (41 women) and analyzed by {HPLC}-{MS}/{MS} to quantify 45 sphingolipids. {S}hotgun metagenomic sequencing of stool was performed to profile the gut microbiome. {R}esults {C}onfirming the link to deteriorated glucose homeostasis, serum ceramides were positively correlated with fasting glucose, but inversely correlated with fasting and {OGTT}-derived measures of insulin sensitivity and beta-cell function. {S}ignificant associations with gut dysbiosis were demonstrated, with {SM} and ceramides being inversely correlated with gene richness. {C}eramides with fatty acid chain lengths of 20-24 carbons were the most associated with low richness. {D}iet-induced weight loss, which improved gene richness, decreased most sphingolipids. {T}hirty-one {MGS}, mostly corresponding to unidentified bacteria species, were inversely correlated with ceramides, including a number of {B}ifidobacterium and {M}ethanobrevibacter smithii. {H}igher ceramide levels were also associated with increased metagenomic modules for lipopolysaccharide synthesis and flagellan synthesis, two pathogen-associated molecular patterns, and decreased enrichment of genes involved in methanogenesis and bile acid metabolism. {C}onclusion {T}his study identifies an association between gut microbiota richness, ceramides, and diabetes risk in overweight/obese humans, and suggests that the gut microbiota may contribute to dysregulation of lipid metabolism in metabolic disorders.},
  keywords = {{M}icrobiome ; {C}eramides ; {S}phingolipids ; {E}ndotoxin ; {G}lucose metabolism},
  booktitle = {},
  journal = {{M}etabolomics},
  volume = {15},
  numero = {11},
  pages = {art. 140 [13]},
  ISSN = {1573-3882},
  year = {2019},
  DOI = {10.1007/s11306-019-1596-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077828},
}